Tatar Arzu, Ozmen Hilal Kiziltunc, Yoruk Ozgur
Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, Ataturk University, Turkey. Email:
Asian Pac J Cancer Prev. 2018 Sep 26;19(9):2403-2407. doi: 10.22034/APJCP.2018.19.9.2403.
Prediction of tumor volume using the Cavalieri method may be helpful in management of therapy and evaluation of treatment results. The aim of this study was to adapt the Cavalieri stereological method to magnetic resonance imaging for determining volume of nasopharyngeal cancers and assess changes after treatment using the Cavalieri method. Serial MRI images in the sagittal plane were obtained from a total of 33 patients with nasopharyngeal carcinomas (11 with stage T2, 11 with stage T3, and 11 with stage T4 lesions). The images were analyzed retrospectively before and two months following the cessation of radiochemotherapy for comparison. Average tumor volumes before and after treatment in patients with stage T2 were 21. 5±10.5 cm3 and 2.82±3.43 cm3, respectively (p=0.000). The respective figures were 35.1±19.0 cm3 and 6.27±7.82 cm3 (p=0.000) for stage T3 cases, and 62.8±27.8 cm3 and 11. 6±11.9 cm3 (p=0.000) for stage T4. Post-treatment tumor volumes were statistically reduced when compared to pre-treatment volumes in all stages.
使用卡瓦列里方法预测肿瘤体积可能有助于治疗管理和治疗结果评估。本研究的目的是将卡瓦列里体视学方法应用于磁共振成像，以确定鼻咽癌的体积，并使用卡瓦列里方法评估治疗后的变化。共从33例鼻咽癌患者（11例T2期、11例T3期和11例T4期病变）获取矢状面的系列MRI图像。在放化疗结束前和结束后两个月对图像进行回顾性分析以作比较。T2期患者治疗前和治疗后的平均肿瘤体积分别为21.5±10.5 cm³和2.82±3.43 cm³（p = 0.000）。T3期病例的相应数值分别为35.1±19.0 cm³和6.27±7.82 cm³（p = 0.000），T4期为62.8±27.8 cm³和11.6±11.9 cm³（p = 0.000）。与各阶段治疗前体积相比，治疗后肿瘤体积有统计学意义的减小。
