Balasundram Sathesh, Salekan Khairuzi, Ahmad Shariffuddin Fadya Nabiha, Taib Nur Aishah, Adnan Tassha Hilda
Department of General Surgery, Hospital Sultanah Nora Ismail, Batu Pahat, Johor, Malaysia. Email:
Asian Pac J Cancer Prev. 2018 Sep 26;19(9):2409-2415. doi: 10.22034/APJCP.2018.19.9.2409.
Objective: To gauge surgical outcome in breast cancer patients with particular reference to overall survival and recurrence free survival among breast cancer patients in Hospital Sultanah Nora Ismail Batu Pahat, Johor, Malaysia. Methods: Patients undergoing ablative breast cancer surgery were identified and clinical records were assessed. Inclusion criteria for enrolment were stage I-IV breast malignancy necessitating resection with or without radiotherapy/ chemotherapy from 2007 to 2013. All individuals had a pre-operative assessment. The post operative assessment period ranged from 1 year to 5 years. Survival distributions were analyzed using Kaplan-Meier curves. Results: A total of 121 patients were included in this study, with an age range of 28-78 years. Some 98% had undergone local excision/ lumpectomy/ mastectomy with axillary clearance. While 81% of patients underwent chemotherapy, only 69% had radiotherapy. Tumours were oestrogen receptor positive in 58% of cases and progesterone receptor positive in 62%. Local recurrence was detected in 10%. The mean age at diagnosis was 51.3 + 10.4 years. The overall survival analysis was based on 22 deaths among the 121 patients (18.2%). Three-year and five-year survival rates were 87.6% and 78.4%, respectively. Analysis of recurrence-free-survival (RFS) was based on 12 events among 121 patients. The Kaplan-Meier RFS analysis revealed that in 90% of the patients with recurrence, it occurred within 45 months. The five year RFS rate was 84.5%. The median time taken from diagnosis to ablative surgery was 51 days (upper limit of 791 days). Only distant metastasis was a significant factor that impacted on both overall survival and recurrence-free survival (p<0.001). Conclusion: Overall survival among our breast cancer patients in our facility is comparable to other in other tertiary centres in the country. A trend for earlier detection was noted.
评估马来西亚柔佛州峇株巴辖苏丹娜诺拉伊斯梅尔医院乳腺癌患者的手术结果，特别关注其总生存期和无复发生存期。方法：确定接受乳腺癌切除手术的患者，并评估其临床记录。纳入标准为2007年至2013年期间需要进行切除手术（无论是否联合放疗/化疗）的I-IV期乳腺恶性肿瘤患者。所有患者均进行了术前评估。术后评估期为1年至5年。使用Kaplan-Meier曲线分析生存分布情况。结果：本研究共纳入121例患者，年龄范围为28-78岁。约98%的患者接受了局部切除/肿块切除术/乳房切除术并进行了腋窝清扫。虽然81%的患者接受了化疗，但只有69%的患者接受了放疗。58%的病例肿瘤雌激素受体呈阳性，62%的病例孕激素受体呈阳性。10%的患者检测到局部复发。诊断时的平均年龄为51.3±10.4岁。总生存期分析基于121例患者中的22例死亡（18.2%）。三年和五年生存率分别为87.6%和78.4%。无复发生存期（RFS）分析基于121例患者中的12例事件。Kaplan-Meier RFS分析显示，90%的复发患者在45个月内复发。五年RFS率为84.5%。从诊断到切除手术的中位时间为51天（上限为791天）。只有远处转移是影响总生存期和无复发生存期的重要因素（p<0.001）。结论：我们医院乳腺癌患者的总生存期与该国其他三级中心相当。注意到有早期检测的趋势。
