Laboratory of Molecular Cell Biology, Centre for DNA Fingerprinting & Diagnostics (CDFD), Inner Ring Road, Uppal, Hyderabad, India. 500 039.
Graduate Studies, Manipal University, Manipal, Karnataka, India. 576 104.
Future Microbiol. 2018 Sep;13:1301-1328. doi: 10.2217/fmb-2018-0013. Epub 2018 Sep 26.
Lipid metabolism is thought to play a key role in the pathogenicity of several intracellular bacteria. Bacterial lipolytic enzymes hydrolyze lipids from the host cell to release free fatty acids which are used as an energy source and building blocks for the synthesis of cell envelope and also to modulate host immune responses. In this review, we discussed the role of lipid metabolism and lipolytic enzymes in the life cycle and virulence of Mycobacterium tuberculosis and other intracellular bacteria. The lipolytic enzymes appear to be potential candidates for developing novel therapeutics by targeting lipid metabolism for controlling M. tuberculosis and other intracellular pathogenic bacteria. [Formula: see text].
脂质代谢被认为在几种胞内细菌的致病机制中起着关键作用。细菌脂解酶从宿主细胞中水解脂质，释放出游离脂肪酸，这些脂肪酸被用作能量来源和细胞壁合成的构建块，并调节宿主的免疫反应。在这篇综述中，我们讨论了脂质代谢和脂解酶在结核分枝杆菌和其他胞内细菌的生命周期和毒力中的作用。脂解酶似乎是通过靶向脂质代谢来开发控制结核分枝杆菌和其他胞内致病性细菌的新型治疗药物的潜在候选物。
