Coyo Natalia, Leiva Marta, Costa Daniel, Rios José, Peña Teresa
Am J Vet Res. 2018 Oct;79(10):1087-1092. doi: 10.2460/ajvr.79.10.1087.
OBJECTIVE To determine corneal thickness (CT), endothelial cell density (ECD), and morphological and morphometric features of caprine eyes and to assess effects of aging on these variables. SAMPLE 27 healthy eyes of 19 Murciano-Granadina goats. PROCEDURES Goats were classified into 2 age groups (kids, 14 months old [14 eyes]; and adults, 7 to 10 years old [13 eyes]). The ECD and CT were calculated in the central cornea and 4 peripheral quadrants. Mean cell area (MCA), pleomorphism (percentage of hexagonal cells), and polymegathism were evaluated in the central cornea. RESULTS Median values for kids were determined for ECD (3,831 cells/mm; inter-quartile [25th to 75th percentile] range [IQR], 3,669 to 4,011 cells/mm), CT (608 μm; IQR, 573 to 655 μm), MCA (255 μm; IQR, 243 to 272 μm), pleomorphism (80.53%; IQR, 78.83% to 83.30%), and polymegathism (19; IQR, 18 to 22). Median values for adults were determined for ECD (2,101 cells/mm; IQR, 1,966 to 2,251 cells/mm), CT (706 μm; IQR, 670 to 730 μm), MCA (466 μm; IQR, 425 to 507 μm), pleomorphism (67.80%; IQR, 65.50% to 70.00%), and polymegathism (21; IQR, 15 to 26). Values differed significantly between the 2 groups for all variables, except polymegathism. For both groups, the dorsal and temporal quadrants were the thickest and thinnest, respectively. Ventral ECD was the lowest for both groups. CONCLUSIONS AND CLINICAL RELEVANCE ECD decreased with age, whereas MCA, pleomorphism, and CT increased. Moreover, differences among regions of the cornea indicated that the central cornea should not be considered as representative of the entire cornea.
目的 确定山羊眼睛的角膜厚度（CT）、内皮细胞密度（ECD）以及形态和形态测量特征，并评估衰老对这些变量的影响。样本 19 只穆尔西亚 - 格拉纳迪纳山羊的 27 只健康眼睛。方法 将山羊分为 2 个年龄组（幼羊，14 个月大 [14 只眼睛]；成年羊，7 至 10 岁 [13 只眼睛]）。计算中央角膜和 4 个周边象限的 ECD 和 CT。评估中央角膜的平均细胞面积（MCA）、多形性（六边形细胞百分比）和大小不均一性。结果 确定幼羊组的 ECD（3831 个细胞/mm；四分位间距 [第 25 至 75 百分位数] 范围 [IQR]，3669 至 4011 个细胞/mm）、CT（608 μm；IQR，573 至 655 μm）、MCA（255 μm；IQR，243 至 272 μm）、多形性（80.53%；IQR，78.83% 至 83.30%）和大小不均一性（19；IQR，18 至 22）的中位数。确定成年羊组的 ECD（2101 个细胞/mm；IQR，1966 至 2251 个细胞/mm）、CT（706 μm；IQR，670 至 730 μm）、MCA（466 μm；IQR，425 至 507 μm）、多形性（67.80%；IQR，65.50% 至 70.00%）和大小不均一性（21；IQR，15 至 26）的中位数。除大小不均一性外，两组所有变量的值均有显著差异。对于两组，背侧和颞侧象限分别最厚和最薄。两组腹侧 ECD 均最低。结论及临床意义 ECD 随年龄增长而降低，而 MCA、多形性和 CT 增加。此外，角膜各区域之间的差异表明，中央角膜不应被视为整个角膜的代表。
