耐黏菌素和碳青霉烯类肺炎克雷伯菌临床分离株：阿尔及利亚
Colistin- and Carbapenem-Resistant Klebsiella pneumoniae Clinical_Isolates: Algeria.
作者信息
Yousfi Hanane, Hadjadj Linda, Dandachi Iman, Lalaoui Rym, Merah Adil, Amoura Kamel, Dahi Ahlem, Dekhil Mazouz, Messalhi Naima, Diene Seydina M, Baron Sophie, Rolain Jean-Marc
机构信息
1 Aix Marseille University , IRD, APHM, MEPHI, IHU-Mediterranean Infection, Marseille, France .
2 Microbiology Department, Annaba University Hospital , Annaba, Algeria .
出版信息
Microb Drug Resist. 2019 Mar;25(2):258-263. doi: 10.1089/mdr.2018.0147. Epub 2018 Sep 25.
This study investigates the molecular mechanisms of colistin and carbapenem resistance in Klebsiella pneumoniae ST101 strains. The three K. pneumoniae carried bla, bla, and bla genes and two coharbored bla. As for colistin resistance, the isolates had amino acid substitutions in PmrA/B and a truncated mgrB gene in one isolate.
本研究调查了肺炎克雷伯菌ST101菌株对黏菌素和碳青霉烯类耐药的分子机制。这三株肺炎克雷伯菌携带bla、bla和bla基因，其中两株共同携带bla。至于对黏菌素的耐药性，分离株在PmrA/B中有氨基酸替换，且其中一株分离株有截短的mgrB基因。
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