AGD：动脉瘤基因数据库。
AGD: Aneurysm Gene Database.
机构信息
Department of Biomedical Informatics, Department of Physiology and Pathophysiology, Center for Noncoding RNA Medicine, MOE Key Lab of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, Beijing, China.
Center of Bioinformatics, Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
出版信息
Database (Oxford). 2018 Jan 1;2018:bay100. doi: 10.1093/database/bay100.
An aneurysm is an outward bulge on an arterial wall. Aneurysms are becoming a serious public health concern as the worldwide population ages. Unfortunately, no effective drugs have been developed for aneurysms to date. In addition, aneurysms may be associated with grave prognosis due to conditions such as ruptures and recurrence. Altogether, these factors make earlier aneurysm prevention, diagnosis and intervention strategies even more important. A bioinformatics resource for aneurysm-associated molecules would be helpful for addressing the above issues; however, such a tool is not yet available. In this study, we developed Aneurysm Gene Database (AGD) for the above purpose. AGD contains 1472 aneurysm-gene associations, including 29 types of aneurysms, 967 protein-coding genes, 29 miRNAs, 6 lncRNAs and several other types of molecules. Users can search, browse and download content in AGD. We believe that AGD is a valuable resource that can help us better understand aneurysms and discover novel treatment targets.
动脉瘤是动脉壁上的向外膨出。随着全球人口老龄化，动脉瘤成为一个严重的公共卫生问题。不幸的是，迄今为止，尚无针对动脉瘤的有效药物。此外，由于破裂和复发等情况，动脉瘤可能与严重的预后相关。总之，这些因素使得早期动脉瘤预防、诊断和干预策略变得更加重要。动脉瘤相关分子的生物信息学资源将有助于解决上述问题；然而，目前尚没有这样的工具。在这项研究中，我们为上述目的开发了动脉瘤基因数据库（AGD）。AGD 包含 1472 个动脉瘤基因关联，包括 29 种动脉瘤、967 个蛋白编码基因、29 个 miRNA、6 个 lncRNA 以及其他几种类型的分子。用户可以在 AGD 中搜索、浏览和下载内容。我们相信 AGD 是一个有价值的资源，可以帮助我们更好地了解动脉瘤并发现新的治疗靶点。
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