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在塞拉利昂农村减少家访后对一项基于社区的抗逆转录病毒治疗项目的评估:一项为期24个月的回顾性研究。

Evaluation of a community-based ART programme after tapering home visits in rural Sierra Leone: a 24-month retrospective study.

作者信息

Kelly J Daniel, Frankfurter Raphael, Lurton Gregoire, Conteh Sulaiman, Empson Susannah F, Daboh Fodei, Kargbo Brima, Giordano Thomas, Mukherjee Joia, Barrie M Bailor

机构信息

a School of Medicine , University of California at San Francisco , San Francisco , CA , USA.

b National HIV/AIDS Secretariat , Freetown , Sierra Leone.

出版信息

SAHARA J. 2018 Dec;15(1):138-145. doi: 10.1080/17290376.2018.1527244.

Abstract

Evaluations of community-based antiretroviral therapy (ART) programmes have demonstrated positive outcomes, but little is known about the impact of tapering community-based ART. The objective of this study was to assess 24-month HIV retention outcomes of a community-based ART programme and its tapered visit frequency in Koidu City, Sierra Leone. This retrospective, quasi-experimental study compared outcomes of 52 HIV-infected persons initiated on community-based ART against 91 HIV-infected persons receiving the standard of care from November 2009 to February 2013. The community-based ART pilot programme was designed to strengthen the standard of care through a comprehensive, patient-centred case management strategy. The strategy included medical, educational, psychological, social, and economic support. Starting in October 2011, the frequency of home visits was tapered from twice daily every day per week to once daily three days per week. Outcomes were retention in care at 12 and 24 months and adherence to ART over a three-month time period. Participants who received community-based ART had significantly higher retention than those receiving standard of care. At 12 months, retention rates for community-based ART and standard of care were 61.5% and 31.9%, respectively (p < .01). At 24 months, retention rates for community-based ART and standard of care were 73.1% and 44.0%, respectively (p < .01). Significant differences in levels of adherence were observed when comparing community-based ART against persons receiving standard of care (p < .05). No differences in adherence levels were observed between groups of people receiving various frequencies of home visits. Our pilot programme in Koidu City provides new evidence that community-based ART has the potential to improve retention and adherence outcomes for HIV-infected persons, regardless of the frequency of home visits. Overcoming the barriers to HIV care requires a comprehensive, patient-centred approach that may include clinic-based and community-based interventions.

摘要

对基于社区的抗逆转录病毒疗法(ART)项目的评估已显示出积极成果,但对于逐步减少基于社区的ART的影响却知之甚少。本研究的目的是评估在塞拉利昂科伊杜市一个基于社区的ART项目及其逐渐减少的访视频率的24个月HIV留存结果。这项回顾性、准实验性研究比较了2009年11月至2013年2月期间开始接受基于社区的ART的52名HIV感染者与91名接受标准治疗的HIV感染者的结果。基于社区的ART试点项目旨在通过全面、以患者为中心的病例管理策略加强标准治疗。该策略包括医疗、教育、心理、社会和经济支持。从2011年10月开始,家访频率从每周每天两次逐渐减少到每周三天每天一次。结果指标为12个月和24个月的治疗留存率以及三个月期间的ART依从性。接受基于社区的ART的参与者的留存率显著高于接受标准治疗的参与者。在12个月时,基于社区的ART和标准治疗的留存率分别为61.5%和31.9%(p<0.01)。在24个月时,基于社区的ART和标准治疗的留存率分别为73.1%和44.0%(p<0.01)。将基于社区的ART与接受标准治疗的人员进行比较时,观察到依从性水平存在显著差异(p<0.05)。在接受不同家访频率的人群组之间未观察到依从性水平的差异。我们在科伊杜市的试点项目提供了新的证据,即基于社区的ART有潜力改善HIV感染者的留存率和依从性结果,无论家访频率如何。克服HIV治疗的障碍需要一种全面、以患者为中心的方法,可能包括基于诊所和基于社区干预措施。

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