Ennis M, Aston-Jones G
Neurosci Lett. 1986 Nov 21;71(3):299-305. doi: 10.1016/0304-3940(86)90637-3.
Our recent anatomic experiments reveal major innervation of the nucleus locus coeruleus (LC) from the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla. In the present studies, low intensity, single pulse electrical stimulation of the PGi synaptically activated most LC neurons examined (69%), while a smaller percentage of LC cells (20%) exhibited pure inhibitory responses. Pharmacologic experiments suggest that the excitatory response may be mediated by an amino acid transmitter.
我们最近的解剖学实验揭示了位于延髓嘴侧腹外侧的巨细胞旁核（PGi）对蓝斑核（LC）的主要神经支配。在本研究中，对PGi进行低强度单脉冲电刺激，通过突触作用激活了大多数被检测的LC神经元（69%），而较小比例的LC细胞（20%）表现出纯抑制性反应。药理学实验表明，兴奋性反应可能由一种氨基酸递质介导。
