Donertas-Ayaz Basak, Caudle Robert M
Department of Oral and Maxillofacial Surgery, University of Florida, Gainesville, FL, United States.
Neurobiol Pain. 2023 Mar 20;13:100124. doi: 10.1016/j.ynpai.2023.100124. eCollection 2023 Jan-Jul.
Trigeminal neuralgia is the most common neuropathic pain involving the craniofacial region. Due to the complex pathophysiology, it is therapeutically difficult to manage. Noradrenaline plays an essential role in the modulation of arousal, attention, cognitive function, stress, and pain. The locus coeruleus, the largest source of noradrenaline in the brain, is involved in the sensory and emotional processing of pain. This review summarizes the knowledge about the involvement of noradrenaline in acute and chronic trigeminal pain conditions and how the activity of the locus coeruleus noradrenergic neurons changes in response to acute and chronic pain conditions and how these changes might be involved in pain-related comorbidities including anxiety, depression, and sleep disturbance.
三叉神经痛是最常见的累及颅面部区域的神经性疼痛。由于其复杂的病理生理学机制，在治疗上难以处理。去甲肾上腺素在调节觉醒、注意力、认知功能、应激和疼痛方面起着重要作用。蓝斑是大脑中去甲肾上腺素的最大来源，参与疼痛的感觉和情绪处理。本综述总结了关于去甲肾上腺素在急性和慢性三叉神经痛中的作用的知识，以及蓝斑去甲肾上腺素能神经元的活动如何响应急性和慢性疼痛状况而变化，以及这些变化可能如何与包括焦虑、抑郁和睡眠障碍在内的疼痛相关合并症有关。
