沙特消化不良患者幽门螺杆菌感染的患病率及相关因素
Prevalence and factors associated with H. pylori infection in Saudi patients with dyspepsia.
作者信息
Akeel Mohammed, Elmakki Erwa, Shehata Atef, Elhafey Ahmed, Aboshouk Thanaa, Ageely Hussein, Mahfouz Mohammed Salih
机构信息
Department of Anatomy, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
Department of Internal Medicine, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
出版信息
Electron Physician. 2018 Sep 9;10(9):7279-7286. doi: 10.19082/7279. eCollection 2018 Sep.
BACKGROUND
Helicobacter pylori (H. pylori) is a major cause of peptic ulcer disease (PUD) and chronic active gastritis that may progress to gastric cancer. Globally, it has been estimated that 50% or more of the world's population is infected by H. pylori, making it the most widespread infection across the globe.
OBJECTIVES
To determine the prevalence of H. pylori infection and to identify factors associated with H. pylori infection in Saudi patients presenting with dyspepsia.
METHODS
In this prospective cross-sectional study, a total of 404 gastric biopsies were endoscopically obtained from 404 patients with dyspepsia from September 2014 to April 2016 (Jazan Province, Saudi Arabia). The specimens were analyzed using the real-time polymerase chain reaction (PCR). The data was examined using descriptive statistics as well as determining the prevalence, and employing Chi square and Fisher exact test. A p-value of ≤0.05 was considered statistically significant in examining the research hypotheses.
RESULTS
The overall prevalence of H. pylori in Jazan Province was 46.5% (95% CI: 41.7-51.4) and the prevalence was lower among those > 55 years old. Prevalence was higher among urban (50.0%; 95% CI: 43.1-56.8) versus rural (42.1%; 95% CI: 35.1-49.3), but with no significant difference. Prevalence did not show significant difference among different Body Mass Index (BMI) categories, ranging from 40.2% to 47.7%. The prevalence of H. pylori in females was 47.1% (95% CI: 40.4-53.9) versus 45.6% (95% CI: 38.7-52.6) in males. Histopathology findings were associated with H. pylori infection with prevalence of 58.1% among patients with chronic active gastritis, compared to 24.1% and 34.8% among mild and chronic gastritis, respectively.
CONCLUSION
Our results indicate that there is a high prevalence of H. pylori among Saudi patients with dyspepsia. Prevalence of H. pylori was high in ages below 55 years. Chronic active gastritis was significantly associated with H. pylori infection. In depth studies are needed to determine associated factors with of H pylori infection in the region.
背景
幽门螺杆菌（H. pylori）是消化性溃疡病（PUD）和慢性活动性胃炎的主要病因，慢性活动性胃炎可能会发展为胃癌。据估计，全球50%或更多的人口感染了幽门螺杆菌，使其成为全球传播最广泛的感染源。
目的
确定沙特消化不良患者中幽门螺杆菌感染的患病率，并确定与幽门螺杆菌感染相关的因素。
方法
在这项前瞻性横断面研究中，2014年9月至2016年4月（沙特阿拉伯贾赞省），通过内镜从404例消化不良患者中获取了404份胃活检样本。使用实时聚合酶链反应（PCR）对样本进行分析。采用描述性统计方法对数据进行检查，确定患病率，并采用卡方检验和Fisher精确检验。在检验研究假设时，p值≤0.05被认为具有统计学意义。
结果
贾赞省幽门螺杆菌的总体患病率为46.5%（95%置信区间：41.7 - 51.4），55岁以上人群的患病率较低。城市地区的患病率（50.0%；95%置信区间：43.1 - 56.8）高于农村地区（42.1%；95%置信区间：35.1 - 49.3），但差异无统计学意义。不同体重指数（BMI）类别之间的患病率没有显著差异，范围在40.2%至47.7%之间。女性幽门螺杆菌的患病率为47.1%（95%置信区间：40.4 - 53.9），男性为45.6%（95%置信区间：38.7 - 52.6）。组织病理学结果与幽门螺杆菌感染相关，慢性活动性胃炎患者中的患病率为58.1%，而轻度和慢性胃炎患者中的患病率分别为24.1%和34.8%。
结论
我们的结果表明，沙特消化不良患者中幽门螺杆菌的患病率很高。55岁以下人群中幽门螺杆菌的患病率很高。慢性活动性胃炎与幽门螺杆菌感染显著相关。需要进行深入研究以确定该地区幽门螺杆菌感染的相关因素。
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