Jha Niharika, Alexander Emy, Kanish Bimal, Badyal Dinesh K
Department of Dermatology, Dr BC Roy Post Graduate Institute of Pediatric Sciences, Kolkata, West Bengal, India.
Department of Dermatology, Christian Medical College and Hospital, Ludhiana, Punjab, India.
Indian Dermatol Online J. 2018 Sep-Oct;9(5):299-303. doi: 10.4103/idoj.IDOJ_81_18.
Cutaneous adverse drug eruptions are the most common adverse reactions attributed to drugs in which any type of skin reaction can be mimicked, induced, or aggravated.
To study the pattern of various types of cutaneous adverse drug reactions (CADRs), to find out the causative drug(s) involved and to determine the response to treatment and outcome in patients with CADRs.
This prospective study was done in the department of dermatology. Patients with suspected drug rash, of either sex and all age groups were included in the study.
Frequencies and proportions were calculated using Chi-square test and -test as the tests of significance. Data was analyzed using SPSS version 21.
A total of 258 patients were enrolled in the study. The most common CADR observed in the study was exanthematous drug eruption in 42.63% patients followed by drug induced urticaria in 21.32% patients. Antimicrobials were the most common offending drugs in 64.73% of patients, followed by non-steroidal anti-inflammatory drugs (NSAIDs) in 15.50% patients. In the study, 12 patients (4.65%) were found to have severe cutaneous adverse drug reactions (SCADRs). Stevens-Johnson syndrome (SJS) - Toxic epidermal necrolysis (TEN) was the most common SCADR (50%) and antituberculous drugs were the most common causative group of drugs causing SCADRs.
The most common CADR observed in the study was exanthematous drug eruption and antimicrobials were the most common causative drugs.
皮肤药物不良反应是药物引起的最常见不良反应，其中任何类型的皮肤反应都可能被模仿、诱发或加重。
研究各类皮肤药物不良反应（CADR）的模式，找出相关致病药物，并确定CADR患者的治疗反应和结局。
本前瞻性研究在皮肤科进行。纳入所有年龄组、男女疑似药物疹患者。
采用卡方检验和t检验计算频率和比例作为显著性检验。使用SPSS 21版软件分析数据。
本研究共纳入258例患者。研究中观察到的最常见CADR是发疹性药疹，占42.63%的患者，其次是药物性荨麻疹，占21.32%的患者。抗菌药物是64.73%患者中最常见的致病药物，其次是非甾体抗炎药（NSAIDs），占15.50%的患者。研究中，12例患者（4.65%）被发现有严重皮肤药物不良反应（SCADR）。史蒂文斯-约翰逊综合征（SJS）-中毒性表皮坏死松解症（TEN）是最常见的SCADR（50%），抗结核药物是导致SCADR最常见的致病药物组。
研究中观察到的最常见CADR是发疹性药疹，抗菌药物是最常见的致病药物。
