基于诱导多能干细胞的年龄相关性黄斑变性（AMD）治疗：通往成功之路需要的不仅仅是盲目信仰。
iPSC-based treatment of age-related macular degeneration (AMD): The path to success requires more than blind faith.
作者信息
Li Fei, Hu Jim, He Tong-Chuan
机构信息
The Editorial Office of Genes & Diseases, Chongqing Medical University, Chongqing, 400046, China.
Department of Pathology and Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 0A4, Canada.
出版信息
Genes Dis. 2017 Apr 1;4(2):41-42. doi: 10.1016/j.gendis.2017.03.001. eCollection 2017 Jun.
Abstract
Induced pluripotent stem cells (iPSCs) hold great promise for the treatment of human diseases. Two recent first-of-its-kind clinical case reports on the iPSC-based treatment of age-related macular degeneration (AMD) highlight the hopes and challenges associated with the clinical application of iPSCs.
摘要
诱导多能干细胞（iPSC）在人类疾病治疗方面极具前景。最近有两篇关于基于iPSC治疗年龄相关性黄斑变性（AMD）的同类首个临床病例报告，突出了与iPSC临床应用相关的希望和挑战。
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Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration.自体诱导干细胞衍生的视网膜细胞治疗黄斑变性。
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Achilles' heel of pluripotent stem cells: genetic, genomic and epigenetic variations during prolonged culture.多能干细胞的致命弱点：长期培养过程中的遗传、基因组和表观遗传变异
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