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3D生物打印技术在诱导多能干细胞组织工程中的应用。

Applications of 3D Bioprinting Technology in Induced Pluripotent Stem Cells-Based Tissue Engineering.

作者信息

Shukla Arvind Kumar, Gao Ge, Kim Byoung Soo

机构信息

School of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Korea.

Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.

出版信息

Micromachines (Basel). 2022 Jan 20;13(2):155. doi: 10.3390/mi13020155.

DOI:10.3390/mi13020155
PMID:35208280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8876961/
Abstract

Induced pluripotent stem cells (iPSCs) are essentially produced by the genetic reprogramming of adult cells. Moreover, iPSC technology prevents the genetic manipulation of embryos. Hence, with the ensured element of safety, they rarely cause ethical concerns when utilized in tissue engineering. Several cumulative outcomes have demonstrated the functional superiority and potency of iPSCs in advanced regenerative medicine. Recently, an emerging trend in 3D bioprinting technology has been a more comprehensive approach to iPSC-based tissue engineering. The principal aim of this review is to provide an understanding of the applications of 3D bioprinting in iPSC-based tissue engineering. This review discusses the generation of iPSCs based on their distinct purpose, divided into two categories: (1) undifferentiated iPSCs applied with 3D bioprinting; (2) differentiated iPSCs applied with 3D bioprinting. Their significant potential is analyzed. Lastly, various applications for engineering tissues and organs have been introduced and discussed in detail.

摘要

诱导多能干细胞（iPSC）本质上是通过成体细胞的基因重编程产生的。此外，iPSC技术可避免对胚胎进行基因操作。因此，由于有安全保障，它们在组织工程中使用时很少引发伦理问题。多项累积成果已证明iPSC在先进再生医学中的功能优势和潜能。最近，3D生物打印技术出现了一种新趋势，即采用更全面的方法进行基于iPSC的组织工程。本综述的主要目的是让人们了解3D生物打印在基于iPSC的组织工程中的应用。本综述根据iPSC的不同用途讨论了其生成方式，分为两类：（1）应用于3D生物打印的未分化iPSC；（2）应用于3D生物打印的分化iPSC。分析了它们的巨大潜力。最后，详细介绍并讨论了工程化组织和器官的各种应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/370ea75cf4e1/micromachines-13-00155-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/5febaa11fc87/micromachines-13-00155-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/55b9316d5a07/micromachines-13-00155-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/fc4fde4aafd4/micromachines-13-00155-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/ca115d4f0de9/micromachines-13-00155-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/496b4f650a83/micromachines-13-00155-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/bc7b8b66a7e0/micromachines-13-00155-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/55a84120df3c/micromachines-13-00155-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/e3e648c5ea4c/micromachines-13-00155-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/a6cbf7a450dc/micromachines-13-00155-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/370ea75cf4e1/micromachines-13-00155-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/5febaa11fc87/micromachines-13-00155-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/55b9316d5a07/micromachines-13-00155-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/fc4fde4aafd4/micromachines-13-00155-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/ca115d4f0de9/micromachines-13-00155-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/496b4f650a83/micromachines-13-00155-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/bc7b8b66a7e0/micromachines-13-00155-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/55a84120df3c/micromachines-13-00155-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/e3e648c5ea4c/micromachines-13-00155-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/a6cbf7a450dc/micromachines-13-00155-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e0/8876961/370ea75cf4e1/micromachines-13-00155-g010.jpg

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