Starkman M N, Schteingart D E, Schork M A
Psychiatry Res. 1986 Nov;19(3):177-88. doi: 10.1016/0165-1781(86)90096-x.
Twenty-three patients with pituitary adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome were studied before and after treatment. The relationship between the amelioration of the depressive syndrome and changes in cortisol and ACTH levels was investigated. There was a significant difference in mean change in 24-hour urinary free cortisol (UFC) excretion for changes in the depressed mood score from first to last visit. There were also significant correlations between decreases in UFC and decreases in both the depressed mood score and the modified Hamilton depression score. These relationships were not found for ACTH. Furthermore, with cortisol decreased to normal levels, continued high ACTH levels did not prevent improvement in depressed mood. The possibility that cortisol may also play a role in the pathogenesis and/or maintenance of the mood disorder in psychiatric patients is discussed.
对23例垂体促肾上腺皮质激素（ACTH）依赖性库欣综合征患者在治疗前后进行了研究。探讨了抑郁综合征改善与皮质醇和ACTH水平变化之间的关系。从首次就诊到末次就诊，抑郁情绪评分变化的24小时尿游离皮质醇（UFC）排泄平均变化存在显著差异。UFC降低与抑郁情绪评分和改良汉密尔顿抑郁评分降低之间也存在显著相关性。ACTH未发现这些关系。此外，随着皮质醇降至正常水平，持续的高ACTH水平并未阻止抑郁情绪的改善。文中讨论了皮质醇可能在精神疾病患者情绪障碍的发病机制和/或维持中也起作用的可能性。
