Starkman M N, Schteingart D E, Schork M A
Psychosom Med. 1981 Feb;43(1):3-18. doi: 10.1097/00006842-198102000-00002.
Thirty-five consecutive patients with Cushing's syndrome were studied prospectively prior to treatment. A consistent constellation of psychiatric disturbances was found, including impairments in affect (depressed mood and crying), cognitive functions (decreased concentration and memory), and vegetative functions (decreased libido and insomnia). A statistically significant relationship was found between the overall psychiatric disability rating and cortisol and ACTH level. The relationship of depressed mood and hormone levels was examined. Low ACTH levels were significantly associated with milder rather than pronounced depressed mood. The implications of the similarities in psychiatric manifestations between Cushing's syndrome and the primary affective disorders are discussed.
对35例库欣综合征患者在治疗前进行了前瞻性研究。发现了一系列一致的精神障碍，包括情感障碍（情绪低落和哭泣）、认知功能障碍（注意力和记忆力下降）以及植物神经功能障碍（性欲减退和失眠）。发现总体精神残疾评分与皮质醇和促肾上腺皮质激素水平之间存在统计学上的显著关系。研究了情绪低落与激素水平的关系。低促肾上腺皮质激素水平与较轻而非明显的情绪低落显著相关。讨论了库欣综合征与原发性情感障碍在精神症状表现上相似性的意义。
