Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Adv Exp Med Biol. 2018;1087:35-38. doi: 10.1007/978-981-13-1426-1_3.
circRNAs are a novel class of ncRNAs that unlike other ncRNAs are not linear and have a circular structure. These valuable ncRNAs have been detected in a wide range of organisms from plants to animals and in all cell lines and tissues. Commonly, circRNAs have several functions as gene expression regulation at transcriptional or posttranscriptional level, miRNA partnership, and splicing intercede. Currently, circRNAs are roughly remarked in a widespread collection of diseases, and circRNAs simply can be recognized in liquid samples for disease detection and progression assessment. Considering these features of circRNAs, these molecules are evolving the impeccable collection of original biomarkers for disease therapy and diagnosis. As the critical role of these molecules in different aspects medicine and biology, circRNAs are considered as key and critical class of ncRNA in the current ncRNA search field. To simplify the assessment of diverse features of circRNAs, several databases have been established such as circBase, CircInteractome, CircNet, Circ2Traits, CircR2Disease, TCSD, and CSCD. In this chapter, we have an overview on these main circRNA databases and introduce key features of each database.
circRNAs 是一类新型的 ncRNAs，与其他 ncRNAs 不同，它们不是线性的，而是具有环形结构。这些有价值的 ncRNAs 已经在从植物到动物的各种生物以及所有细胞系和组织中被检测到。通常，circRNAs 具有多种功能，如转录或转录后水平的基因表达调控、miRNA 结合和剪接干预。目前，circRNAs 在广泛的疾病中被粗略地描述，并且可以在液体样本中简单地识别它们，用于疾病检测和进展评估。考虑到 circRNAs 的这些特征，这些分子正在成为疾病治疗和诊断的原始生物标志物的完美集合。由于这些分子在医学和生物学的不同方面的重要作用，circRNAs 被认为是当前 ncRNA 研究领域中关键和重要的 ncRNA 类别。为了简化对 circRNAs 不同特征的评估，已经建立了几个数据库，如 circBase、CircInteractome、CircNet、Circ2Traits、CircR2Disease、TCSD 和 CSCD。在本章中，我们概述了这些主要的 circRNA 数据库，并介绍了每个数据库的关键特征。
