环状 RNAs 作为 miRNA 的海绵。

Circular RNAs Act as miRNA Sponges.

机构信息

Institute of Life Sciences, Bhubaneswar, Odisha, India.

出版信息

Adv Exp Med Biol. 2018;1087:67-79. doi: 10.1007/978-981-13-1426-1_6.

Abstract

Majority of RNAs expressed in animal cells lack protein-coding ability. Unlike other cellular RNAs, circular (circ)RNAs include a large family of noncoding (nc)RNAs that lack the 5' or 3' ends. The improvements in high-throughput RNA sequencing and novel bioinformatics tools have led to the identification of thousands of circRNAs in various organisms. CircRNAs can regulate gene expression by influencing the transcription, the mRNA turnover, and translation by sponging RNA-binding proteins and microRNAs. Given the broad impact of circRNA on miRNA activity, there is huge interest in understanding the impact of miRNA sponging by circRNA on gene regulation. In this review, we summarize our current knowledge of the miRNA-circRNA interaction and mechanisms that influence gene expression.

摘要

真核细胞中表达的大多数 RNA 缺乏蛋白质编码能力。与其他细胞 RNA 不同，环状（circ）RNA 包括一大类非编码（nc）RNA，它们缺乏 5' 或 3' 末端。高通量 RNA 测序和新型生物信息学工具的改进，已经在各种生物中鉴定出数千种 circRNA。circRNA 可以通过影响转录、mRNA 周转和翻译来调节基因表达，从而与 RNA 结合蛋白和 microRNAs 结合。鉴于 circRNA 对 miRNA 活性的广泛影响，人们非常有兴趣了解 circRNA 通过 miRNA 海绵作用对基因调控的影响。在这篇综述中，我们总结了我们目前对 miRNA-circRNA 相互作用和影响基因表达的机制的认识。