Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, Shanghai, China.
MetroWest Medical Center, Framingham, MA, USA.
Adv Exp Med Biol. 2018;1087:299-308. doi: 10.1007/978-981-13-1426-1_24.
Every year, millions of people around the world suffer from different forms of tissue trauma. Regenerative medicine refers to therapy that replaces the injured organ or cells. Stem cells are the frontiers and hotspots of current regenerative medicine research. Circular RNAs (circRNAs) are essential for the early development of many species. It was found that they could guide stem cell differentiation through interacting with certain microRNAs (miRNAs). Based on this concept, it is meaningful to look into how circRNAs influence stem cells and its role in regenerative medicine. In this chapter we will discuss the functional roles of circRNAs in the prevention, repair, or progression of chronic diseases, through the communication between stem cells.
每年，全世界数以百万计的人遭受不同形式的组织创伤。再生医学是指替代受损器官或细胞的治疗方法。干细胞是当前再生医学研究的前沿和热点。环状 RNA（circRNAs）是许多物种早期发育所必需的。研究发现，它们可以通过与某些 microRNAs（miRNAs）相互作用来指导干细胞分化。基于这一概念，研究 circRNAs 如何影响干细胞及其在再生医学中的作用具有重要意义。在本章中，我们将讨论 circRNAs 通过干细胞之间的通讯在预防、修复或慢性疾病进展中的功能作用。
