将食管鳞状细胞癌中Tpm1.6和Tpm1.7的下调视为一种有效的生物标志物。
Considering the downregulation of Tpm1.6 and Tpm1.7 in squamous cell carcinoma of esophagus as a potent biomarker.
作者信息
Zare Maryam, Hadi Faranak, Alivand Mohammad Reza
机构信息
Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, Iran.
Department of Biology, Faculty of Sciences, Lorestan University, Khorramabad, Iran.
出版信息
Per Med. 2018 Sep;15(5):361-370. doi: 10.2217/pme-2018-0015. Epub 2018 Sep 27.
AIM
Squamous cell carcinoma of esophagus (SCCE) is an aggressive disease with a poor prognosis. Tropomyosins attach to actin microfilaments, providing its stability. Nonmuscle cells express Tpm isoforms such as Tpm1.6 and Tpm1.7 which are involved in cytoskeleton functional properties regulation.
MATERIALS & METHODS: The expression of Tpm1.6 and Tpm1.7 was analyzed in SCCE tissues and its association with clinicopathological parameters and survival of patients was assessed.
RESULTS
Tpm1.6 and Tpm1.7, besides TPM1 mRNA decreased considerably in SCCE tissues relative to normal esophageal tissues (p < 0.001). TPM1 downregulation level was significantly associated with the degree of tumor differentiation (p = 0.017).
CONCLUSION
Tpm1.6 and Tpm1.7 suppression play a crucial role in esophagus tumorigenesis and could be associated with SCCE poor prognosis.
目的
食管鳞状细胞癌（SCCE）是一种侵袭性疾病，预后较差。原肌球蛋白附着于肌动蛋白微丝，维持其稳定性。非肌肉细胞表达Tpm亚型，如Tpm1.6和Tpm1.7，它们参与细胞骨架功能特性的调节。
材料与方法
分析SCCE组织中Tpm1.6和Tpm1.7的表达，并评估其与临床病理参数及患者生存率的关系。
结果
与正常食管组织相比，SCCE组织中Tpm1.6和Tpm1.7以及TPM1 mRNA显著降低（p < 0.001）。TPM1下调水平与肿瘤分化程度显著相关（p = 0.017）。
结论
Tpm1.6和Tpm1.7的抑制在食管肿瘤发生中起关键作用，可能与SCCE的不良预后相关。
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