Department of Medicine, Section of General Pathology, School of Medicine, University of Verona, Verona, Italy.
Immunology. 2019 Jan;156(1):23-32. doi: 10.1111/imm.13005. Epub 2018 Oct 10.
An increasing body of literature supports a role for neutrophils as players in the orchestration of adaptive immunity. During acute and chronic inflammatory conditions, neutrophils rapidly migrate not only to sites of inflammation, but also to draining lymph nodes and spleen, where they engage bidirectional interactions with B- and T-lymphocyte subsets. Accordingly, a relevant role of neutrophils in modulating B-cell responses under homeostatic conditions has recently emerged. Moreover, specialized immunoregulatory properties towards B or T cells acquired by distinct neutrophil populations, originating under pathological conditions, have been consistently described. In this article, we summarize the most recent data from human studies and murine models on the ability of neutrophils to modulate adaptive immune responses under physiological and pathological conditions and the mechanisms behind these processes.
越来越多的文献支持中性粒细胞在调节适应性免疫中发挥作用。在急性和慢性炎症情况下，中性粒细胞不仅迅速迁移到炎症部位，还迁移到引流的淋巴结和脾脏，在那里它们与 B 细胞和 T 细胞亚群发生双向相互作用。因此，中性粒细胞在调节稳态条件下 B 细胞反应方面具有重要作用。此外，在病理条件下产生的不同中性粒细胞群获得的针对 B 细胞或 T 细胞的专门免疫调节特性也得到了一致描述。在本文中，我们总结了来自人类研究和小鼠模型的最新数据，这些数据涉及中性粒细胞在生理和病理条件下调节适应性免疫反应的能力以及这些过程背后的机制。
