School of Psychology and Clinical Language Sciences, University of Reading, UK.
J Psychopharmacol. 2018 Oct;32(10):1067-1074. doi: 10.1177/0269881118799935. Epub 2018 Sep 27.
Given the heterogeneity within depression, in this study we aim to examine how resting-state functional connectivity (RSFC) in adolescents is related to anhedonia and depression severity on a continuum in line with the research domain criteria (RDoC) approach.
We examined how RSFC in the dorsal medial prefrontal cortex (dmPFC), nucleus accumbens (NAcc) and pregenual anterior cingulate cortex (pgACC) was related to anhedonia and depression severity in 86 adolescents (13-21 years).
We found both anhedonia and depression severity related to decreased dmPFC RSFC with the precuneus, a part of the default mode network. However we also found that increased dmPFC connectivity with the ACC/paracingulate gyrus related to anhedonia whereas increased RSFC with the frontal pole related to depression severity.
This work extends the view that the dmPFC is a potential therapeutic target for depression in two ways: 1. We report dmPFC connectivity in adolescents; and 2. We show different dmPFC RSFC specific to anhedonia and depression severity, providing neural targets for intervention in young people at risk of depression.
鉴于抑郁症的异质性，本研究旨在根据研究领域标准（RDoC）方法，考察青少年静息态功能连接（RSFC）与快感缺失和抑郁严重程度连续体的关系。
我们考察了背内侧前额叶皮层（dmPFC）、伏隔核（NAcc）和前扣带回皮质前嘴部（pgACC）的 RSFC 与 86 名青少年（13-21 岁）的快感缺失和抑郁严重程度的关系。
我们发现快感缺失和抑郁严重程度均与 dmPFC 与默认模式网络一部分的后扣带回之间的 RSFC 降低有关。然而，我们还发现 dmPFC 与 ACC/旁扣带回之间的连接增加与快感缺失有关，而与额极之间的 RSFC 增加与抑郁严重程度有关。
这项工作从两个方面扩展了 dmPFC 是治疗抑郁症的潜在靶点的观点：1. 我们报告了青少年 dmPFC 的连接；2. 我们显示了与快感缺失和抑郁严重程度特异性相关的不同 dmPFC RSFC，为有抑郁风险的年轻人的干预提供了神经靶点。
