Rzepa Ewelina, McCabe Ciara
School of Psychology and Clinical Language Sciences, University of Reading, UK.
School of Psychology and Clinical Language Sciences, University of Reading, UK.
J Psychiatr Res. 2016 Nov;82:40-7. doi: 10.1016/j.jpsychires.2016.07.013. Epub 2016 Jul 18.
Previous studies have found dysfunctional resting state functional connectivity (RSFC) in depressed patients. Examining RSFC might aid biomarker discovery for depression. However RSFC in young people at risk of depression has yet to be examined. 35 healthy adolescents (13-18 yrs old.) were recruited. 17 scoring high on the Mood and Feelings Questionnaire (MFQ > 27 (High Risk: HR), and 18 scoring low on the MFQ < 15 (Low Risk: LR) matched on age and gender. We selected seed regions in the salience network (SN: amygdala and pregenual anterior cingulate cortex (pgACC)) and the central executive network (CEN: dorsal medial prefrontal cortex (dmPFC)). Mood and anhedonia measures were correlated with brain connectivity. We found decreased RSFC in the HR group between the amygdala and the pgACC and hippocampus and precuneus. We also found decreased RSFC in the HR group between the pgACC and the putamen and between the dmPFC and the precuneus. The pgACC RSFC with the insula/orbitofrontal cortex correlated inversely with the anticipation of pleasure in all subjects. Increased RSFC was observed between the pgACC and the prefrontal cortex and the amygdala and the temporal pole in the HR group compared to the LR group. Our findings are the first to show that adolescents with depression symptoms have dysfunctional RSFC between seeds in the SN and CEN with nodes in the Default Mode Network. As increased connectivity between the pgACC and the insula correlated with decreased ability to anticipate pleasure, we suggest this might be mechanism underlying the risk of experiencing anhedonia, a suggested biomarker for depression.
先前的研究发现抑郁症患者存在静息态功能连接（RSFC）功能失调。检查RSFC可能有助于发现抑郁症的生物标志物。然而，处于抑郁风险中的年轻人的RSFC尚未得到研究。招募了35名健康青少年（13 - 18岁）。17名在情绪与情感问卷上得分高（MFQ > 27（高风险：HR）），18名在MFQ上得分低（< 15（低风险：LR）），两组在年龄和性别上匹配。我们在突显网络（SN：杏仁核和膝前扣带回皮质（pgACC））和中央执行网络（CEN：背内侧前额叶皮质（dmPFC））中选择了种子区域。情绪和快感缺失测量与脑连接性相关。我们发现HR组中杏仁核与pgACC、海马体与楔前叶之间的RSFC降低。我们还发现HR组中pgACC与壳核之间以及dmPFC与楔前叶之间的RSFC降低。在所有受试者中，pgACC与脑岛/眶额皮质的RSFC与愉悦预期呈负相关。与LR组相比，HR组中pgACC与前额叶皮质之间以及杏仁核与颞极之间观察到RSFC增加。我们的研究结果首次表明，有抑郁症状的青少年在突显网络和中央执行网络中的种子区域与默认模式网络中的节点之间存在功能失调的RSFC。由于pgACC与脑岛之间连接性增加与愉悦预期能力降低相关，我们认为这可能是快感缺失风险的潜在机制，而快感缺失是抑郁症的一个潜在生物标志物。
