State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Adv Mater. 2019 Sep;31(38):e1801159. doi: 10.1002/adma.201801159. Epub 2018 Sep 9.
With their hierarchical structures and the substantial surface areas, hollow particles have gained immense research interest in biomedical applications. For scalable fabrications, emulsion-based approaches have emerged as facile and versatile strategies. Here, the recent achievements in this field are unfolded via an "emulsion particulate strategy," which addresses the inherent relationship between the process control and the bioactive structures. As such, the interior architectures are manipulated by harnessing the intermediate state during the emulsion revolution (intrinsic strategy), whereas the external structures are dictated by tailoring the building blocks and solidification procedures of the Pickering emulsion (extrinsic strategy). Through integration of the intrinsic and extrinsic emulsion particulate strategy, multifunctional hollow particles demonstrate marked momentum for label-free multiplex detections, stimuli-responsive therapies, and stem cell therapies.
具有分级结构和较大比表面积的中空粒子在生物医学应用中引起了广泛的研究兴趣。对于可扩展的制造，基于乳液的方法已经成为一种简单而通用的策略。在这里，通过“乳液颗粒策略”展开了该领域的最新成果，该策略解决了过程控制和生物活性结构之间的内在关系。通过利用乳液转变过程中的中间状态（内在策略）来操纵内部结构，而通过调整 Pickering 乳液的构建块和固化程序（外在策略）来控制外部结构。通过整合内在和外在的乳液颗粒策略，多功能中空粒子在无标记多重检测、刺激响应治疗和干细胞治疗方面展现出显著的发展势头。
