Suppr超能文献

重组鉴定、分子分类和乙型肝炎病毒参考基因组的建议。

Recombinant identification, molecular classification and proposed reference genomes for hepatitis delta virus.

机构信息

Biomedical Research Center, Northwest Minzu University, Lanzhou, China.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.

出版信息

J Viral Hepat. 2019 Jan;26(1):183-190. doi: 10.1111/jvh.13010. Epub 2018 Oct 19.

Abstract

Hepatitis delta virus (HDV), as a defective sub-virus that co-infects with hepatitis B virus, imposes an emerging global health burden. However, genetic characteristics and molecular classification of HDV remain under investigated. In this study, we have systematically retrieved and analysed a large set of HDV full-length genome sequences and identified novel recombinants. Based on phylogenetic and genetic analyses, we have established an updated classification system for HDV when recombinants were excluded. Furthermore, we have mapped the global distribution of different genotypes and subtypes. Finally, we have compiled a complete set of reference genomes for each subtype and proposed criteria for future identification of novel genotypes and subtypes. Of note, the global distribution map indicates that currently available HDV genetic data remain limited, and thus our proposed classification will likely evolve as future epidemiological data will accumulate. These results will facilitate the future research on the diagnosis, screening, epidemiology, evolution, prevention and clinical management of HDV infection.

摘要

丁型肝炎病毒(HDV)是一种缺陷亚病毒,与乙型肝炎病毒共同感染,给全球健康带来了新的负担。然而,HDV 的遗传特征和分子分类仍有待研究。在这项研究中,我们系统地检索和分析了大量的 HDV 全长基因组序列,并鉴定了新的重组体。基于系统发育和遗传分析,我们建立了一个排除重组体后的 HDV 最新分类系统。此外,我们绘制了不同基因型和亚型的全球分布图谱。最后,我们为每个亚型编制了完整的参考基因组,并提出了未来鉴定新基因型和亚型的标准。值得注意的是,全球分布图谱表明,目前可用的 HDV 遗传数据仍然有限,因此我们提出的分类可能会随着未来流行病学数据的积累而不断发展。这些结果将有助于未来对 HDV 感染的诊断、筛查、流行病学、进化、预防和临床管理的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/437d/7379554/56e247563f6d/JVH-26-183-g001.jpg

相似文献

1
Recombinant identification, molecular classification and proposed reference genomes for hepatitis delta virus.
J Viral Hepat. 2019 Jan;26(1):183-190. doi: 10.1111/jvh.13010. Epub 2018 Oct 19.
2
Genetic diversity of hepatitis D virus genotype-1 in Europe allows classification into subtypes.
J Viral Hepat. 2019 Jul;26(7):900-910. doi: 10.1111/jvh.13086. Epub 2019 Mar 15.
4
Hepatitis delta virus genetic variability: from genotypes I, II, III to eight major clades?
Curr Top Microbiol Immunol. 2006;307:151-71. doi: 10.1007/3-540-29802-9_8.
5
RNA recombination in Hepatitis delta virus: Identification of a novel naturally occurring recombinant.
J Microbiol Immunol Infect. 2017 Dec;50(6):771-780. doi: 10.1016/j.jmii.2015.10.013. Epub 2015 Nov 27.
6
A comprehensive bioinformatic analysis of hepatitis D virus full-length genomes.
J Viral Hepat. 2018 Jul;25(7):860-869. doi: 10.1111/jvh.12876. Epub 2018 Feb 21.
7
Complete genome sequences and phylogenetic analysis of hepatitis delta viruses isolated from nine Turkish patients.
Arch Virol. 2011 Dec;156(12):2215-20. doi: 10.1007/s00705-011-1120-y. Epub 2011 Oct 5.
8
Molecular epidemiology of hepatitis B and Delta virus strains that spread in the Mediterranean North East Coast of Tunisia.
J Clin Virol. 2015 Nov;72:126-32. doi: 10.1016/j.jcv.2015.10.002. Epub 2015 Oct 8.
10
Detection of hepatitis delta virus recombinants in cultured cells co-transfected with cloned genotypes I and IIb DNA sequences.
J Virol Methods. 2006 Nov;137(2):252-8. doi: 10.1016/j.jviromet.2006.06.022. Epub 2006 Jul 24.

引用本文的文献

2
vHDvDB 2.0: Database and Group Comparison Server for Hepatitis Delta Virus.
Viruses. 2024 Aug 5;16(8):1254. doi: 10.3390/v16081254.
4
The Forgotten Virus, Hepatitis D: A Review of Epidemiology, Diagnosis, and Current Treatment Strategies.
J Clin Exp Hepatol. 2024 Sep-Oct;14(5):101395. doi: 10.1016/j.jceh.2024.101395. Epub 2024 Mar 9.
5
Phylogenetic and Phylodynamic Analysis of Delta Strains Circulating in Italy.
Viruses. 2023 Aug 23;15(9):1791. doi: 10.3390/v15091791.
6
An Insight Into the Factors Affecting the Prevalence and Natural History of Hepatitis D.
Cureus. 2023 Aug 12;15(8):e43362. doi: 10.7759/cureus.43362. eCollection 2023 Aug.
7
Circulation of HDV Genotypes in Brazil: Identification of a Putative Novel HDV-8 Subgenotype.
Microbiol Spectr. 2023 Jun 15;11(3):e0396522. doi: 10.1128/spectrum.03965-22. Epub 2023 Apr 19.

本文引用的文献

1
A comprehensive bioinformatic analysis of hepatitis D virus full-length genomes.
J Viral Hepat. 2018 Jul;25(7):860-869. doi: 10.1111/jvh.12876. Epub 2018 Feb 21.
2
Genetic diversity and worldwide distribution of the deltavirus genus: A study of 2,152 clinical strains.
Hepatology. 2017 Dec;66(6):1826-1841. doi: 10.1002/hep.29574. Epub 2017 Oct 30.
5
Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.
Lancet Glob Health. 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X.
6
Hepatitis delta: virological and clinical aspects.
Virol J. 2017 Sep 13;14(1):177. doi: 10.1186/s12985-017-0845-y.
7
Hepatitis delta-associated mortality in HIV/HBV-coinfected patients.
J Hepatol. 2017 Feb;66(2):297-303. doi: 10.1016/j.jhep.2016.10.007. Epub 2016 Oct 14.
8
Is Hepatitis Delta infections important in Brazil?
BMC Infect Dis. 2016 Sep 29;16(1):525. doi: 10.1186/s12879-016-1856-9.
9
Hepatitis D Virus: A Call to Screening.
Gastroenterol Hepatol (N Y). 2014 Oct;10(10):647-86.
10
MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.
Mol Biol Evol. 2016 Jul;33(7):1870-4. doi: 10.1093/molbev/msw054. Epub 2016 Mar 22.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验