• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

vHDvDB 2.0：乙型肝炎 Delta 病毒数据库和组比较服务器。

vHDvDB 2.0: Database and Group Comparison Server for Hepatitis Delta Virus.

机构信息

Department of Computer Science and Information Engineering, Chang Gung University, Taoyuan 33302, Taiwan.

Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan.

出版信息

Viruses. 2024 Aug 5;16(8):1254. doi: 10.3390/v16081254.

DOI:10.3390/v16081254
PMID:39205227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11359145/
Abstract

The hepatitis delta virus (HDV) is a unique pathogen with significant global health implications, affecting individuals who are coinfected with the hepatitis B virus (HBV). HDV infection has profound clinical consequences, manifesting either as coinfection with HBV, resulting in acute hepatitis and potential liver failure, or as superinfection in chronic HBV cases, substantially increasing the risk of cirrhosis and hepatocellular carcinoma. Given the complex dynamics of HDV infection and the urgent need for advanced research tools, this article introduces vHDvDB 2.0, a comprehensive HDV full-length sequence database. This innovative platform integrates data preprocessing, secondary structure prediction, and epidemiological research tools. The primary goal of vHDvDB 2.0 is to consolidate HDV sequence data into a user-friendly repository, thereby facilitating access for researchers and enhancing the broader scientific understanding of HDV. The significance of this database lies in its potential to streamline HDV research by providing a centralized resource for analyzing viral sequences and exploring genotype-specific characteristics. It will also enable more in-depth research within the HDV sequence domains.

摘要

丁型肝炎病毒（HDV）是一种具有重要全球健康意义的独特病原体，影响同时感染乙型肝炎病毒（HBV）的个体。HDV 感染具有深远的临床后果，表现为与 HBV 同时感染，导致急性肝炎和潜在的肝功能衰竭，或在慢性 HBV 病例中发生重叠感染，大大增加肝硬化和肝细胞癌的风险。鉴于 HDV 感染的复杂动态和对先进研究工具的迫切需求，本文介绍了 vHDvDB 2.0，这是一个综合性的 HDV 全长序列数据库。这个创新平台集成了数据预处理、二级结构预测和流行病学研究工具。vHDvDB 2.0 的主要目标是将 HDV 序列数据整合到一个用户友好的存储库中，从而为研究人员提供便利，并增强对 HDV 的更广泛的科学理解。该数据库的意义在于，它通过为分析病毒序列和探索基因型特异性特征提供集中资源，能够简化 HDV 研究。它还将使 HDV 序列领域的研究更加深入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/b134cc27d6b8/viruses-16-01254-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/8ece2b70000d/viruses-16-01254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/91765f20028a/viruses-16-01254-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/0e30f12af52a/viruses-16-01254-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/e3c027b5c43d/viruses-16-01254-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/0ccb412103bc/viruses-16-01254-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/5684459de784/viruses-16-01254-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/4cac4c5566a6/viruses-16-01254-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/b134cc27d6b8/viruses-16-01254-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/8ece2b70000d/viruses-16-01254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/91765f20028a/viruses-16-01254-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/0e30f12af52a/viruses-16-01254-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/e3c027b5c43d/viruses-16-01254-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/0ccb412103bc/viruses-16-01254-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/5684459de784/viruses-16-01254-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/4cac4c5566a6/viruses-16-01254-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96b/11359145/b134cc27d6b8/viruses-16-01254-g008.jpg

相似文献

1
vHDvDB 2.0: Database and Group Comparison Server for Hepatitis Delta Virus.vHDvDB 2.0：乙型肝炎 Delta 病毒数据库和组比较服务器。
Viruses. 2024 Aug 5;16(8):1254. doi: 10.3390/v16081254.
2
Molecular epidemiology and clinical characteristics of hepatitis delta virus (HDV) infected patients with elevated transaminases in Shanghai, China.中国上海转氨酶升高的乙型肝炎 delta 病毒（HDV）感染患者的分子流行病学和临床特征。
BMC Infect Dis. 2020 Aug 3;20(1):565. doi: 10.1186/s12879-020-05275-1.
3
Characterization of Hepatitis Delta Virus Among Pregnant Women of Pakistan.巴基斯坦孕妇中乙型肝炎 Delta 病毒的特征。
Viral Immunol. 2019 Oct;32(8):335-340. doi: 10.1089/vim.2019.0048. Epub 2019 Sep 25.
4
Molecular epidemiology of hepatitis delta and hepatitis B viruses circulating in two major provinces (East and North-West) of Pakistan.巴基斯坦两大主要省份（东部和西北部）流行的乙型肝炎病毒和乙型肝炎 delta 病毒的分子流行病学。
Infect Genet Evol. 2018 Oct;64:65-69. doi: 10.1016/j.meegid.2018.06.013. Epub 2018 Jun 12.
5
Exploring genetic diversity of hepatitis D virus full-length genome in Brazil: Discovery of a novel HDV-8 subgenotype beyond African borders.探讨巴西地区丁型肝炎病毒全长基因组的遗传多样性：发现了一种新型丁型肝炎病毒 8 亚型，超出了非洲范围。
Infect Genet Evol. 2024 Nov;125:105671. doi: 10.1016/j.meegid.2024.105671. Epub 2024 Sep 17.
6
Dynamics of hepatitis D (delta) virus genotype 3 in the Amazon region of South America.南美洲亚马逊地区丙型肝炎（德尔塔）病毒 3 型的动态。
Infect Genet Evol. 2011 Aug;11(6):1462-8. doi: 10.1016/j.meegid.2011.05.020. Epub 2011 May 27.
7
Molecular epidemiology of hepatitis B and Delta virus strains that spread in the Mediterranean North East Coast of Tunisia.在突尼斯地中海东北海岸传播的乙型肝炎和丁型肝炎病毒株的分子流行病学
J Clin Virol. 2015 Nov;72:126-32. doi: 10.1016/j.jcv.2015.10.002. Epub 2015 Oct 8.
8
Epidemiological, diagnostic, therapeutic and prognostic impact of hepatitis B and D virus infection on hepatocellular carcinoma: A review of the literature.乙型和丁型肝炎病毒感染对肝细胞癌的流行病学、诊断、治疗和预后影响的文献综述。
Virology. 2024 Dec;600:110273. doi: 10.1016/j.virol.2024.110273. Epub 2024 Oct 22.
9
Clade homogeneity and low rate of delta virus despite hyperendemicity of hepatitis B virus in Ethiopia.尽管埃塞俄比亚乙型肝炎病毒高度流行，但德尔塔病毒的进化枝同质性和低感染率。
Virol J. 2017 Sep 12;14(1):176. doi: 10.1186/s12985-017-0844-z.
10
Higher rate of hepatitis events in patients with human immunodeficiency virus, hepatitis B, and hepatitis D genotype II infection: a cohort study in a medical center in southern Taiwan.台湾南部某医学中心的队列研究：人类免疫缺陷病毒、乙型肝炎和乙型肝炎 D 基因型 II 感染患者中肝炎事件发生率较高。
J Microbiol Immunol Infect. 2015 Feb;48(1):20-7. doi: 10.1016/j.jmii.2013.08.001. Epub 2013 Sep 21.

本文引用的文献

1
Investigating the Genetic Diversity of Hepatitis Delta Virus in Hepatocellular Carcinoma (HCC): Impact on Viral Evolution and Oncogenesis in HCC.探讨肝细胞癌（HCC）中乙型肝炎 delta 病毒的遗传多样性：对 HCC 中病毒进化和致癌作用的影响。
Viruses. 2024 May 21;16(6):817. doi: 10.3390/v16060817.
2
ICTV Virus Taxonomy Profile: 2024.ICTV 病毒分类学简介：2024 年
J Gen Virol. 2024 Feb;105(2). doi: 10.1099/jgv.0.001963.
3
A Mathematical Analysis of HDV Genotypes: From Molecules to Cells.丁型肝炎病毒基因型的数学分析：从分子到细胞
Mathematics (Basel). 2021 Sep 1;9(17). doi: 10.3390/math9172063. Epub 2021 Aug 26.
4
Hepatitis D virus in 2021: virology, immunology and new treatment approaches for a difficult-to-treat disease.2021 年的丁型肝炎病毒：病毒学、免疫学和针对难治性疾病的新治疗方法。
Gut. 2021 Sep;70(9):1782-1794. doi: 10.1136/gutjnl-2020-323888. Epub 2021 Jun 8.
5
Infection by Hepatitis Delta Virus.感染丁型肝炎病毒。
Viruses. 2020 Jun 16;12(6):648. doi: 10.3390/v12060648.
6
HDVdb: A Comprehensive Hepatitis D Virus Database.HDVdb：一个综合性的丁型肝炎病毒数据库。
Viruses. 2020 May 14;12(5):538. doi: 10.3390/v12050538.
7
The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis.全球丁型肝炎病毒感染的流行情况：系统评价和荟萃分析。
J Hepatol. 2020 Sep;73(3):523-532. doi: 10.1016/j.jhep.2020.04.008. Epub 2020 Apr 23.
8
Targeting the Host for New Therapeutic Perspectives in Hepatitis D.以宿主为靶点探索丁型肝炎治疗新前景
J Clin Med. 2020 Jan 14;9(1):222. doi: 10.3390/jcm9010222.
9
Recombinant identification, molecular classification and proposed reference genomes for hepatitis delta virus.重组鉴定、分子分类和乙型肝炎病毒参考基因组的建议。
J Viral Hepat. 2019 Jan;26(1):183-190. doi: 10.1111/jvh.13010. Epub 2018 Oct 19.
10
Genetic diversity and worldwide distribution of the deltavirus genus: A study of 2,152 clinical strains.德尔塔病毒属的遗传多样性和全球分布：对 2152 株临床分离株的研究。
Hepatology. 2017 Dec;66(6):1826-1841. doi: 10.1002/hep.29574. Epub 2017 Oct 30.