Department of Psychiatry and Psychotherapy, and Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, Germany.
Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
Hum Brain Mapp. 2019 Jan;40(1):163-174. doi: 10.1002/hbm.24362. Epub 2018 Sep 10.
Despite a growing number of reports about alterations in intrinsic/resting brain activity observed in patients with psychotic disorders, their relevance to well-established cognitive control deficits in this patient group is not well understood. Totally 88 clinically stabilized patients with a psychotic disorder and 50 healthy controls participated in a resting-state magnetic resonance imaging study (rs-MRI) and performed an antisaccade task in the laboratory to assess voluntary inhibitory control ability. Deficits on this task are a well-established biomarker across psychotic disorders as we found in the present patient sample. First, regional cerebral function was evaluated by measuring the amplitude of low frequency fluctuations (ALFF) in rs-MRI BOLD signals. We found reduced ALFF in patients in regions known to be relevant to antisaccade task performance including bilateral frontal eye fields (FEF), supplementary eye fields (SEF) and thalamus. Second, areas with ALFF alterations were used as seed areas in whole-brain functional connectivity (FC) analysis. Altered FC was observed in a fronto-thalamo-parietal network that was associated with inhibition error rate in patients but not in controls. In contrast, faster time to generate a correct antisaccade was associated with FC in FEF and SEF in controls but this effect was not seen in patients. These findings establish a behavioral relevance of resting-state fMRI findings in psychotic disorders, and extend previous reports of alterations in fronto-thalamo-parietal network activation during antisaccade performance seen in task-based fMRI studies.
尽管越来越多的报告描述了精神病患者内在/静息大脑活动的改变，但这些改变与该患者群体中已确立的认知控制缺陷的相关性尚不清楚。共有 88 名临床稳定的精神病患者和 50 名健康对照者参加了一项静息态磁共振成像研究（rs-MRI），并在实验室中进行了反扫视任务，以评估自愿抑制控制能力。我们在本患者样本中发现，该任务的缺陷是精神病障碍的一种既定生物标志物。首先，通过测量 rs-MRI BOLD 信号中的低频波动幅度（ALFF）来评估区域大脑功能。我们发现，患者在与反扫视任务表现相关的区域中，包括双侧额眼区（FEF）、补充眼区（SEF）和丘脑，ALFF 降低。其次，将具有 ALFF 改变的区域用作全脑功能连接（FC）分析的种子区域。在与患者抑制错误率相关的额-丘脑-顶叶网络中观察到了改变的 FC，但在对照组中没有观察到。相比之下，在对照组中，更快地生成正确的反扫视与 FEF 和 SEF 中的 FC 相关，但在患者中未观察到这种效应。这些发现确立了静息态 fMRI 在精神病障碍中的行为相关性，并扩展了之前关于反扫视任务中基于任务的 fMRI 研究中额-丘脑-顶叶网络激活改变的报告。
