Department of Psychiatry, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.
Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, United Kingdom; Precision Imaging Beacon, University of Nottingham, Nottingham, United Kingdom.
Psychiatry Res Neuroimaging. 2020 Sep 30;303:111139. doi: 10.1016/j.pscychresns.2020.111139. Epub 2020 Jul 15.
Given the emerging evidence in support of parietal brain stimulation to treat speech disorder in psychosis, we investigated structural and functional parietal dysconnectivity in schizophrenia (n = 34) and bipolar disorder with psychotic symptoms (n = 16). We found that both patient groups demonstrated reduced left parietal structural connectivity compared to healthy controls (n = 32). The three groups also differed significantly on the variability of left and right parietal dynamic functional connectivity. In patients with schizophrenia, parietal dysconnectivity predicted the severity of disorganisation symptoms. These findings suggest that dysconnectivity between the parietal lobe and the rest of the brain plays a key role in disorganisation symptoms of schizophrenia.
鉴于越来越多的证据支持顶叶脑刺激治疗精神病中的言语障碍，我们研究了精神分裂症（n=34）和伴有精神病症状的双相情感障碍（n=16）患者的顶叶结构和功能连接障碍。我们发现，与健康对照组（n=32）相比，两组患者的左顶叶结构连接均减少。三组在左、右顶叶动态功能连接的变异性上也有显著差异。在精神分裂症患者中，顶叶连接障碍预测了紊乱症状的严重程度。这些发现表明，顶叶与大脑其他部位之间的连接障碍在精神分裂症的紊乱症状中起着关键作用。
