Abbad A, Baba H, Dehbi H, Elmessaoudi-Idrissi M, Elyazghi Z, Abidi O, Radouani F
Laboratoire d'écologie et d'environnement- Faculté des Sciences Ben M'sik, Université Hassan II de Casablanca, Casablanca, Morocco.
Virologie Médicale et Laboratoire de BSL-3, Institut Pasteur du Maroc, Casablanca, Morocco.
Glob Health Epidemiol Genom. 2018 May 11;3:e8. doi: 10.1017/gheg.2018.8. eCollection 2018.
Breast cancer (BC) is one of the most complex, diverse and leading cause of death in women worldwide. The present investigation aims to explore genes panel associated with BC in different African regions, and compare them to those studied worldwide. We extracted relevant information from 43 studies performed in Africa using the following criteria: case-control study, association between genetic variations and BC risk. Data were provided on mutations and polymorphisms associated with BC without fixing a specific date. Case-only studies and clinical trials were excluded. Our study revealed that the majority of African BC genetic studies remain restricted to the investigation of BRCA1 and BRCA2 genes and differences in their mutations spectrum. Therefore, it is necessary to encourage African researchers to characterize more genes involved in BC using methods generating global information such as next-generation sequencing in order to guide specific and more effective therapeutic strategies for the African community.
乳腺癌（BC）是全球女性中最复杂、最多样化且主要的死因之一。本研究旨在探索不同非洲地区与乳腺癌相关的基因面板，并将其与全球范围内研究的基因进行比较。我们使用以下标准从在非洲进行的43项研究中提取了相关信息：病例对照研究、基因变异与乳腺癌风险之间的关联。提供了与乳腺癌相关的突变和多态性数据，未设定具体日期。仅病例研究和临床试验被排除。我们的研究表明，大多数非洲乳腺癌基因研究仍局限于对BRCA1和BRCA2基因及其突变谱差异的调查。因此，有必要鼓励非洲研究人员使用能生成全局信息的方法，如下一代测序，来鉴定更多与乳腺癌相关的基因，以便为非洲社区制定具体且更有效的治疗策略提供指导。
