Conte Alessandro, Scurrell Emma, Baines Stephen J
Animal Health Trust, Lanwades Park, Kentford, Newmarket, UK.
CytoPath Ltd, Ledbury, UK.
JFMS Open Rep. 2018 Sep 20;4(2):2055116918801033. doi: 10.1177/2055116918801033. eCollection 2018 Jul-Dec.
A solitary, sessile, non-ulcerated, freely mobile cutaneous mass approximately 1 cm in diameter on the left temporal region of a 7-year-old neutered female cat was examined. A fine-needle aspirate and wedge biopsy were performed by the referring veterinary surgeon and indicated a neoplasm of uncertain cell lineage. On histopathological examination, the deep dermis contained a discrete, non-encapsulated and vascular neoplasm with morphological and immunophenotypical features typical of a glomus cell tumour. Neoplastic cells were immunopositive for vimentin, muscle actin and smooth muscle actin, and immunonegative for cytokeratin, S100, desmin and von Willebrand factor (factor VIII-related antigen).
Glomus cell tumours arise from modified smooth muscle cells and are rare in animals, particularly cats. Specific immunohistochemistry is of fundamental importance in the correct diagnosis of these tumours and should be considered for masses when cytology and histology results are inconclusive or uncertain.
对一只7岁已绝育雌性猫左侧颞部的一个孤立、无柄、非溃疡性、可自由移动的直径约1厘米的皮肤肿物进行了检查。转诊兽医外科医生进行了细针抽吸和楔形活检,结果显示为细胞谱系不明的肿瘤。组织病理学检查显示,真皮深层有一个离散的、无包膜的血管性肿瘤,具有典型的球瘤细胞肿瘤的形态学和免疫表型特征。肿瘤细胞波形蛋白、肌动蛋白和平滑肌肌动蛋白免疫阳性,细胞角蛋白、S100、结蛋白和血管性血友病因子(因子VIII相关抗原)免疫阴性。
球瘤细胞肿瘤起源于改良的平滑肌细胞,在动物中罕见,尤其是猫。特异性免疫组织化学对于这些肿瘤的正确诊断至关重要,当细胞学和组织学结果不确定或不明确时,对于肿物应考虑进行此项检查。