Rademeyer Mia, Joubert Pierre
Department of Psychiatry, School of Medicine, University of Pretoria, South Africa.
S Afr J Psychiatr. 2016 May 6;22(1):890. doi: 10.4102/sajpsychiatry.v22i1.890. eCollection 2016.
Cognitive impairment is a core feature of schizophrenia that also has strong prognostic significance. In most clinical settings comprehensive neuropsychological testing to detect cognitive impairment in schizophrenia patients is not readily available, but because cognitive deficits in schizophrenia are clinically important it would be useful to detect or at least screen for them in a clinical setting. Unfortunately there are no validated, brief screening instruments for the detection of cognitive impairment in schizophrenia. Nevertheless, the Montreal Cognitive Assessment Test (MoCA) and the Mini-Mental State Examination (MMSE) show promise in this regard. The objective of this study was to compare the results of the MMSE and MoCA in a group of outpatient schizophrenia sufferers to contribute to research into the instruments' potential usefulness as screening tools for cognitive impairment in schizophrenia.
The Afrikaans versions of the MMSE and MoCA were administered to Afrikaans-speaking adult outpatients. Participants had at least seven years of formal education and had been in partial or full remission for at least 3 months. The MMSE and MoCA scores for each participant were matched and compared using the non-parametric Wilcoxon matched pairs test.
The sample consisted of 30 Afrikaans-speaking outpatients with schizophrenia. The mean MMSE score was 27.17 ± 2.64, and the mean MoCA score was 22.53 ± 3.91. There was a statistically significant difference between participants' performance on the MMSE and MoCA tests ( = 0.000008).
Compared to the MMSE, the MoCA may be a more useful instrument to detect cognitive impairment in patients with schizophrenia. Further studies are required.
认知障碍是精神分裂症的核心特征，也具有很强的预后意义。在大多数临床环境中，用于检测精神分裂症患者认知障碍的全面神经心理学测试并不容易获得，但由于精神分裂症中的认知缺陷在临床上很重要，在临床环境中检测或至少筛查这些缺陷会很有用。不幸的是，目前尚无经过验证的用于检测精神分裂症认知障碍的简短筛查工具。尽管如此，蒙特利尔认知评估测试（MoCA）和简易精神状态检查表（MMSE）在这方面显示出了前景。本研究的目的是比较MMSE和MoCA在一组门诊精神分裂症患者中的测试结果，以推动对这些工具作为精神分裂症认知障碍筛查工具潜在效用的研究。
将MMSE和MoCA的南非荷兰语版本施用于讲南非荷兰语的成年门诊患者。参与者至少接受过七年正规教育，并且已部分或完全缓解至少3个月。使用非参数Wilcoxon配对检验对每位参与者的MMSE和MoCA得分进行匹配和比较。
样本包括30名讲南非荷兰语的精神分裂症门诊患者。MMSE平均得分为27.17 ± 2.64，MoCA平均得分为22.53 ± 3.91。参与者在MMSE和MoCA测试中的表现存在统计学上的显著差异（ = 0.000008）。
与MMSE相比，MoCA可能是检测精神分裂症患者认知障碍更有用的工具。需要进一步研究。
