Olivier Riaan M, Kilian Sanja, Chiliza Bonginkosi, Asmal Laila, Oosthuizen Petrus P, Emsley Robin, Kidd Martin
Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
Department of Statistics and Actuarial Sciences, Stellenbosch University, South Africa.
S Afr J Psychiatr. 2017 Aug 31;23:1049. doi: 10.4102/sajpsychiatry.v23i0.1049. eCollection 2017.
Thought disorder and visual-perceptual deficits have been well documented, but their relationships with clinical symptoms and cognitive function remain unclear. Cognitive-perceptual deficits may underscore clinical symptoms in schizophrenia patients.
This study aimed to explore how thought disorder and form perception are related with clinical symptoms and cognitive dysfunction in first-episode schizophrenia.
Forty-two patients with a first-episode of schizophrenia, schizophreniform or schizoaffective disorder were recruited from community clinics and state hospitals in the Cape Town area.
Patients were assessed at baseline with the Rorschach Perceptual Thinking Index (PTI), the Positive and Negative Syndrome Scale (PANSS) and the MATRICS Cognitive Consensus Battery (MCCB). Spearman correlational analyses were conducted to investigate relationships between PTI scores, PANSS factor analysis-derived domain scores and MCCB composite and subscale scores. Multiple regression models explored these relationships further.
Unexpectedly, poor form perception (X- %) was inversely correlated with the severity of PANSS positive symptoms ( = -0.42, = 0.02). Good form perception (XA%) correlated significantly with speed of processing ( = 0.59, < 0.01), working memory ( = 0.48, < 0.01) and visual learning ( = 0.55, < 0.01). PTI measures of thought disorder did not correlate significantly with PANSS symptom scores or cognitive performance.
Form perception is associated with positive symptoms and impairment in executive function during acute psychosis. These findings suggest that there may be clinical value in including sensory-perceptual processing tasks in cognitive remediation and social cognitive training programmes for schizophrenia patients.
思维障碍和视知觉缺陷已有充分记录，但它们与临床症状和认知功能的关系仍不明确。认知 - 感知缺陷可能是精神分裂症患者临床症状的潜在原因。
本研究旨在探讨首发精神分裂症患者的思维障碍和形状感知与临床症状及认知功能障碍之间的关系。
从开普敦地区的社区诊所和州立医院招募了42例首发精神分裂症、精神分裂症样或分裂情感性障碍患者。
患者在基线时接受罗夏墨迹测验感知思维指数（PTI）、阳性和阴性症状量表（PANSS）以及精神分裂症认知功能成套测验共识版（MCCB）评估。进行Spearman相关性分析以研究PTI分数、PANSS因子分析得出的领域分数与MCCB综合及子量表分数之间的关系。多元回归模型进一步探讨了这些关系。
出乎意料的是，形状感知能力差（X - %）与PANSS阳性症状的严重程度呈负相关（r = -0.42，p = 0.02）。形状感知能力良好（XA%）与加工速度（r = 0.59，p < 0.01）、工作记忆（r = 0.48，p < 0.01）和视觉学习（r = 0.55，p < 0.01）显著相关。思维障碍的PTI测量结果与PANSS症状分数或认知表现无显著相关性。
形状感知与急性精神病期间的阳性症状和执行功能损害相关。这些发现表明，在精神分裂症患者的认知康复和社会认知训练计划中纳入感觉 - 感知加工任务可能具有临床价值。
