脱脂胡椒（L.）籽提取物对高脂饮食诱导的C57BL/6J小鼠肥胖的影响。
Effect of defatted pepper ( L.) seed extracts on high-fat diet-induced obesity in C57BL/6J mice.
作者信息
Sung Jeehye, Yang Jinwoo, Kim Younghwa, Kim Myunghee, Jeong Heon Sang, Lee Junsoo
机构信息
1Division of Food and Animal Sciences, Chungbuk National University, Cheongju, Chungbuk, 28644 Korea.
2School of Food Biotechnology and Nutrition, Kyungsung University, Busan, 48434 Korea.
出版信息
Food Sci Biotechnol. 2016 Oct 31;25(5):1457-1461. doi: 10.1007/s10068-016-0226-0. eCollection 2016.
This study investigated the effect of defatted pepper seed ethanolic extract (DPSE) on high-fat diet-induced obesity in C57BL/6J mice. The mice were fed a normal diet (ND), high fat diet (HFD), or HFD in combination with DPSE (100 and 200mg/kg body weight) for 7 weeks. Supplementing the HFD of mice with DPSE significantly decreased body weight gain and food efficiency ratio induced by HFD. The amount of epididymal fat and size of adipocytes were also dramatically reduced by DPSE supplementation. Although no statistical significance was found between the HFD and HFD plus DPSE groups in plasma fat deposition, liver weight, and hepatic cholesterol contents were significantly reduced in the DPSE-treated group. In conclusion, these results suggest that DPSE could prevent obesity and adiposity. These effects may be important in developing therapeutic agents against obesity in future.
本研究调查了脱脂辣椒籽乙醇提取物（DPSE）对高脂饮食诱导的C57BL/6J小鼠肥胖的影响。将小鼠分为正常饮食（ND）组、高脂饮食（HFD）组或高脂饮食联合DPSE（100和200mg/kg体重）组，喂养7周。用DPSE补充小鼠的高脂饮食可显著降低高脂饮食诱导的体重增加和食物效率比。补充DPSE还可显著减少附睾脂肪量和脂肪细胞大小。虽然高脂饮食组与高脂饮食加DPSE组在血浆脂肪沉积方面未发现统计学差异，但DPSE处理组的肝脏重量和肝胆固醇含量显著降低。总之，这些结果表明DPSE可预防肥胖和肥胖症。这些作用可能对未来开发抗肥胖治疗药物具有重要意义。
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