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红辣椒籽水提取物可抑制高脂饮食诱导的C57BL/6小鼠肥胖。

Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice.

作者信息

Kim Hwa-Jin, You Mi-Kyoung, Wang Ziyun, Lee Young-Hyeon, Kim Hyeon-A

机构信息

Hisol Inc., Namwon-si, Jeollabuk-do, Republic of Korea.

2Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE USA.

出版信息

Food Sci Biotechnol. 2019 Dec 3;29(2):275-281. doi: 10.1007/s10068-019-00710-9. eCollection 2020 Feb.

DOI:10.1007/s10068-019-00710-9
PMID:32064136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6992834/
Abstract

In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.

摘要

在本研究中，研究了红辣椒籽水提取物（RPS）对高脂饮食（HFD）喂养小鼠肥胖的保护作用（HFD对照组，以及用100或200mg/kg体重的RPS处理13周的HFD组）。RPS的应用部分逆转了HFD诱导的体重和脂肪组织重量增加。脂肪组织重量模式与双能X线吸收法（DXA）测量的脂肪面积模式平行。在脂肪组织中，RPS抑制了脂肪生成转录因子和脂肪标记基因的表达。通过RPS处理在脂肪组织中观察到AMP激活蛋白激酶的激活。此外，RPS改善了HFD喂养小鼠的胰岛素抵抗和高脂血症的高稳态模型评估。这些发现表明，RPS可作为一种潜在的治疗物质，用于减少体脂和肥胖相关疾病。

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Food Sci Biotechnol. 2016 Oct 31;25(5):1457-1461. doi: 10.1007/s10068-016-0226-0. eCollection 2016.
2
Red Pepper Seed Inhibits Differentiation of 3T3-L1 Cells during the Early Phase of Adipogenesis via the Activation of AMPK.红辣椒籽通过激活 AMPK 抑制 3T3-L1 细胞在脂肪生成早期的分化。
Am J Chin Med. 2018;46(1):107-118. doi: 10.1142/S0192415X18500064. Epub 2018 Jan 9.
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Phytother Res. 2016 Nov;30(11):1848-1855. doi: 10.1002/ptr.5692. Epub 2016 Aug 19.
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Anti-Obesity and Hypoglycemic Effects of Poncirus trifoliata L. Extracts in High-Fat Diet C57BL/6 Mice.枳椇提取物对高脂饮食C57BL/6小鼠的抗肥胖和降血糖作用
Molecules. 2016 Apr 6;21(4):453. doi: 10.3390/molecules21040453.
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