Department of Food Science and Nutrition, Kyungpook National University, 1370 Sankyuk Dong Puk-ku, 702-701 Daegu, Republic of Korea.
Br J Nutr. 2012 Dec 28;108(12):2166-75. doi: 10.1017/S0007114512000347. Epub 2012 Mar 14.
Consumption of a high-fat diet (HFD) enriched in saturated fat induces excessive weight gain due to adiposity, which can lead to metabolic complications, as well as increased risk of fatty liver disease and CVD. The present study investigated the underlying mechanism and dose-response effects of resveratrol (RV) on obesity, hepatic steatosis and dyslipidaemia in mice fed a HFD. Male C57BL/6J mice were fed a normal diet or a HFD (20 % fat, w/w) combined with 0·005 or 0·02 % (w/w) RV for 10 weeks. As expected, mice fed a HFD developed obesity, as shown by increased body weight gain, visceral fat, hepatic fat and plasma cholesterol. RV significantly reduced visceral fat and plasma NEFA. In the liver of HFD-fed mice, RV significantly reduced TAG and cholesterol, as well as lipid droplet number and size. A low dose of RV (0·005 %) appeared to be more effective than a higher dose of RV (0·02 %) for suppressing adiposity and hepatic steatosis development with a significant decrease in body weight gain, plasma TAG and total cholesterol levels. These changes were seemingly attributable to a suppression of the fatty acid (FA) synthase, glucose-6-phosphate dehydrogenase, and phosphatidate phosphohydrolase and/or an activation of FA oxidation in the liver and epididymal adipose tissue. In conclusion, daily consumption of a low dose of RV is effective for protecting against diet-induced obesity, hepatic steatosis and dyslipidaemia in HFD-fed mice.
高脂肪饮食（HFD）会导致肥胖，从而引起体重过度增加，这可能导致代谢并发症，以及增加患脂肪肝疾病和心血管疾病的风险。本研究探讨了白藜芦醇（RV）对高脂肪饮食喂养的小鼠肥胖、肝脂肪变性和血脂异常的潜在机制和剂量反应。雄性 C57BL/6J 小鼠喂食正常饮食或高脂肪饮食（20%脂肪，w/w），并同时喂食 0·005 或 0·02%（w/w）RV 10 周。正如预期的那样，喂食高脂肪饮食的小鼠体重增加，内脏脂肪、肝脂肪和血浆胆固醇增加，从而出现肥胖。RV 显著降低了内脏脂肪和血浆非酯化脂肪酸（NEFA）。在高脂肪饮食喂养的小鼠肝脏中，RV 显著降低了 TAG 和胆固醇含量，以及脂质滴的数量和大小。低剂量 RV（0·005%）似乎比高剂量 RV（0·02%）更有效，能够抑制肥胖和肝脂肪变性的发展，体重增加、血浆 TAG 和总胆固醇水平显著降低。这些变化似乎归因于肝脏和附睾脂肪组织中脂肪酸（FA）合酶、葡萄糖-6-磷酸脱氢酶和磷酸脂酶的抑制以及 FA 氧化的激活。总之，每天摄入低剂量 RV 可有效预防高脂肪饮食喂养的小鼠肥胖、肝脂肪变性和血脂异常。
