各种人参皂苷、人参根和人参浆果对胰脂肪酶活性的影响。
Effects of various ginsenosides and ginseng root and ginseng berry on the activity of Pancreatic lipase.
作者信息
Li Zhipeng, Ji Geun Eog
机构信息
1Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, 151-742 Republic of Korea.
Research Institute, Bifido Co., Ltd., Hongcheon, 250-804 Republic of Korea.
出版信息
Food Sci Biotechnol. 2017 Jun 8;26(3):767-773. doi: 10.1007/s10068-017-0090-6. eCollection 2017.
Although ginsenosides Rb1, Rb2, Rc, and Rd and ginseng extracts are shown to inhibit pancreatic lipase (PL) activity, the effects of the other ginsenosides, particularly the deglycosylated ones that are considered to show stronger biological activities than the glycosylated forms, are not clear. In this study, we observed the effects of various ginsenosides on PL activity. Results showed that the effects vary with each individual ginsenoside. Ginsenosides Rb1, Rd, Rg1, Rg3, and compound K significantly suppressed 43, 47, 75, and 55% of PL activity at the concentration of 100 μg/mL, respectively. Rg3 was discovered to be the most effective among various common ginsenosides, with a minimum effective concentration of 6.25 μg/mL. Ginsenosides F2 and Rf slightly enhanced PL activity. In addition, fermentation markedly enhanced the inhibitory effect of the ginseng root and ginseng berry, which might be attributed to the changes of ginsenoside profiles.
虽然人参皂苷Rb1、Rb2、Rc和Rd以及人参提取物已被证明可抑制胰脂肪酶（PL）的活性，但其他人参皂苷的作用尚不清楚，尤其是那些被认为比糖基化形式具有更强生物活性的去糖基化人参皂苷。在本研究中，我们观察了各种人参皂苷对PL活性的影响。结果表明，每种人参皂苷的作用各不相同。人参皂苷Rb1、Rd、Rg1、Rg3和化合物K在浓度为100μg/mL时，分别显著抑制了43%、47%、75%和55%的PL活性。Rg3被发现是各种常见人参皂苷中最有效的，最低有效浓度为6.25μg/mL。人参皂苷F2和Rf略微增强了PL活性。此外，发酵显著增强了人参根和人参浆果的抑制作用，这可能归因于人参皂苷谱的变化。
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