Skulachev V P
Biokhimiia. 1986 Dec;51(12):1925-9.
A scheme of the respiratory chain is presented, according to which three delta mu H-generators (complexes I, III and IV) provide for the transmembrane transport of ten H+ ions per atom of adsorbed O2. It is assumed that all the three delta mu H-generators operate in accordance with the same mechanism, namely, they translocate electrons at a distance averaging 1/2 of membrane width, whereas protons moving in the opposite direction pass the other halfwidth across the membrane. A redox cycle functions in each of the three sites of the energy coupling mechanism: the flavin (F) cycle in complex I, the Q-cycle in complex III and the O-cycle in complex IV. These cycles are interconnected by mobile carriers: the F- and Q-cycles by ubiquinone and the Q- and O-cycles by cytochrome c.
本文提出了呼吸链的一种模式，据此三个ΔμH产生体（复合体I、III和IV）每吸附一个氧原子可实现十个H⁺离子的跨膜转运。假定这三个ΔμH产生体均按相同机制运行，即它们在平均为膜宽度一半的距离上转移电子，而沿相反方向移动的质子则穿过膜的另一半宽度。能量偶联机制的三个位点各有一个氧化还原循环发挥作用：复合体I中的黄素（F）循环、复合体III中的Q循环以及复合体IV中的O循环。这些循环通过可移动载体相互连接：F循环和Q循环通过泛醌连接，Q循环和O循环通过细胞色素c连接。
