Department of Radiology, Kindai University Faculty of Medicine , Osaka-Sayama , Japan.
Int J Radiat Biol. 2019 Oct;95(10):1427-1430. doi: 10.1080/09553002.2018.1516910. Epub 2018 Sep 28.
Radionuclide therapy (RNT) involves the selective delivery of radiation, emitted from radionuclides to tumors or target organs. The techniques of RNT are increasingly being used for the treatment of various tumors. The purpose of this article is to report on the current state of RNT, to clarify the issues of radiation protection associated with RNT, and to show future prospects. Medical exposure of patients has unique features; application of dose limits is not undertaken, and justification and optimization do apply but in a different way from in other exposures. The expanding use of RNT has raised concern regarding potential carcinogenic and leukemogenic effects and research on second primary cancer after RNT have been developing. RNT combined with imaging and dosimetry and featuring a theranostic approach is undergoing a significant expansion, and such dosimetry-based treatment planning leads to individualization, or personalization, which is likely to improve the effectiveness and safety of patient management in RNT.
放射性核素治疗（RNT）涉及从放射性核素选择性地向肿瘤或靶器官输送辐射。RNT 技术越来越多地用于治疗各种肿瘤。本文旨在报告 RNT 的现状，阐明与 RNT 相关的辐射防护问题，并展示未来的前景。患者的医疗照射具有独特的特点；不进行剂量限值的应用，正当性和优化适用，但与其他照射的方式不同。RNT 的广泛应用引起了对潜在致癌和白血病效应的关注，并且对 RNT 后第二原发癌的研究正在发展。RNT 与成像和剂量测定相结合，采用治疗诊断方法，正在显著扩展，这种基于剂量测定的治疗计划导致个体化或个性化，这可能会提高 RNT 中患者管理的有效性和安全性。
