[MОRPHOLOGICAL HEPATIC CHANGES IN RATS WHILE CCL(4) —ІNDUCED CIRRHOSIS AND HEPATIC ENCEPHALOPATHY ON BACKGROUND OF TREATMENT].

Impact of choline alphoscerate on morphological hepatic indices in rats with hepatic cirrhosis and hepatic encephalopathy, caused by injection of 15% solution of CCl(4) during 4 weeks, in comparison to standard scheme of treatment, was studied. Reduction of the hepatic histological changes severity, of the injured hepatocytes volume, of stromal—parenchymal ratio and enhancement of nucleo—cytoplasmic ratio in rats with hepatic cirrhosis under the choline alphoscerate impact were noted. The fibrosis and histological activity index in accordance to Knodell's scale witnessed a reduction of severity of hepatic affection in rats, which were treated, using choline alphoscerate.