从全缘黄连木中分离出的黄连木酸的肌肉松弛活性。
Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima.
作者信息
Rauf Abdur, Bawazeer Saud, Uddin Ghias, Siddiqui Bina S, Khan Haroon, Ben Hadda Taibi, Mabkhot Yahia Nasser, Shaheen Usama, Ramadan Mohamed Fawzy
机构信息
Department of Chemistry, University of Swabi, Anbar-23561, Khyber Pakhtunkhwa, Pakistan.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 42, Saudi Arabia.
出版信息
Z Naturforsch C J Biosci. 2018 Nov 27;73(11-12):413-416. doi: 10.1515/znc-2017-0179.
The aim of the current work was to explore the muscle relaxant effect of pistagremic acid (PA) isolated from Pistacia integerrima in various animal paradigms. In a rotarod test, PA caused a significant (p<0.05) muscle relaxant potential in a dose-dependent manner. When studied in the inclined plane test, pretreatment with PA (5 and 10 mg/kg) caused promising activity (p<0.05) after treatment for 30, 60 and 90 min. The muscle relaxant potential of PA was strongly complimented by the traction and chimney tests, showing a dominant effect after 60 min of treatment. In conclusion, PA possesses strong muscle relaxant activity in various animal-based models.
当前研究的目的是探讨从全缘黄连木中分离得到的波斯黄连木酸（PA）在各种动物模型中的肌肉松弛作用。在转棒试验中，PA以剂量依赖性方式产生显著（p<0.05）的肌肉松弛潜力。在倾斜平面试验中进行研究时，用PA（5和10mg/kg）预处理在治疗30、60和90分钟后产生了有前景的活性（p<0.05）。PA的肌肉松弛潜力在牵引和烟囱试验中得到了有力证实，在治疗60分钟后显示出显著效果。总之，PA在各种基于动物的模型中具有强大的肌肉松弛活性。
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