从黄连木 Pistacia integerrima Stewart 中分离得到的新的杀利什曼原虫三萜酸 pistagremic acid。
Pistagremic acid a new leishmanicidal triterpene isolated from Pistacia integerrima Stewart.
机构信息
Institute of Chemical Sciences, Centre for Phytomedicine & Medicinal Organic Chemistry, University of Peshawar, Peshawar, Pakistan.
出版信息
J Enzyme Inhib Med Chem. 2012 Oct;27(5):646-8. doi: 10.3109/14756366.2011.604853. Epub 2011 Aug 18.
The present study was designed to investigate the whole plant of Pistacia integerrima Stewart in order to examine the pharmacological basis of the use of the plant in folk medicine for the treatment of infectious diseases and disorder. Phytochemical and pharmacological studies led to the isolation of a new triterpene pistagremic acid (3-methyl-7-(4,4,10,13,14-pentamethyl-3-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-oct-3-enoic). Pistagremic acid showed significant leishmanicidal activity (IC(50): 6.71 ± 0.09 µM) against Leishmania major (DESTO) promastigotes in comparison to standard compound amphotericin B (IC(50): 0.21 ± 0.06 µM).
本研究旨在对黄连木的全植物进行研究，以考察该植物在民间医学中用于治疗传染病和紊乱的药理学基础。植物化学和药理学研究导致分离出一种新的三萜类化合物 pistagremic 酸（3-甲基-7-（4,4,10,13,14-五甲基-3-2,3,4,5,6,7,10,11,12,13,14,15,16,17-十六氢-1H-环戊[a]菲-17-基）-辛-3-烯酸）。与标准化合物两性霉素 B（IC50：0.21±0.06μM）相比，pistagremic 酸对利什曼原虫（DESTO）前鞭毛体表现出显著的杀利什曼原虫活性（IC50：6.71±0.09μM）。
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