人类细胞中 DNA 复制起始的调控。
Regulation of the initiation of DNA replication in human cells.
机构信息
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
DNA Repair (Amst). 2018 Dec;72:99-106. doi: 10.1016/j.dnarep.2018.09.003. Epub 2018 Sep 12.
Abstract
The origin of species would not have been possible without high fidelity DNA replication and complex genomes evolved with mechanisms that control the initiation of DNA replication at multiple origins on multiple chromosomes such that the genome is duplicated once and only once. The mechanisms that control the assembly and activation of the replicative helicase and the initiation of DNA replication in yeast and Xenopus egg extract systems have been identified and reviewed [1,2]. The goal of this review is to organize currently available data on the mechanisms that control the initiation of DNA replication in human cells.
摘要
没有高保真的 DNA 复制，物种的起源就不可能实现；而复杂的基因组则是通过多种机制进化而来的，这些机制可以控制在多个染色体的多个起点开始 DNA 复制，从而使基因组只复制一次。在酵母和非洲爪蟾卵提取物系统中，已经鉴定和综述了控制复制解旋酶组装和激活以及 DNA 复制起始的机制[1,2]。本篇综述的目的是整理目前关于控制人细胞中 DNA 复制起始的机制的可用数据。
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