Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Deutschordenstrasse 50, 60327, Frankfurt am Main, Germany.
Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstrasse 14, 72076, Tübingen, Germany.
Neuroimage. 2019 Jan 1;184:621-631. doi: 10.1016/j.neuroimage.2018.09.066. Epub 2018 Sep 25.
The tendency to interpret nonverbal social signals as hostile in intention is associated with aggressive responding, poor social functioning and mental illness, and can already be observed in childhood. To investigate the neural correlates of such hostile attributions of social intention, we performed a functional magnetic imaging study in 10-18 year old children and adolescents. Fifty healthy participants rated videos of laughter, which they were told to imagine as being directed towards them, as friendly versus hostile in social intention. Hostile intention ratings were associated with neural response in the right temporal voice area (TVA). Moreover, self-reported trait physical aggression modulated this relationship in both the right TVA and bilateral lingual gyrus, with stronger associations between hostile intention ratings and neural activation in children with higher trait physical aggression scores. Functional connectivity results showed decreased connectivity between the right TVA and left dorsolateral prefrontal cortex with increasing trait physical aggression for making hostile social intention attributions. We conclude that children's social intention attributions are more strongly related to activation of early face and voice-processing regions with increasing trait physical aggression.
将非言语社会信号解释为具有敌意意图的倾向与攻击性反应、社交功能不良和精神疾病有关，这种倾向甚至在儿童时期就可以观察到。为了研究这种对社会意图的敌意归因的神经相关性，我们对 10-18 岁的儿童和青少年进行了功能磁共振成像研究。50 名健康参与者对他们被告知想象为针对他们的笑声视频进行友好与敌对的社会意图评级。敌意意图评级与右侧颞语音区（TVA）的神经反应有关。此外，自我报告的特质身体攻击性调节了右侧 TVA 和双侧舌回中的这种关系，具有更高特质身体攻击性评分的儿童中，敌意意图评级与神经激活之间的关联更强。功能连接结果显示，随着特质身体攻击性的增加，进行敌意社会意图归因时，右侧 TVA 与左侧背外侧前额叶皮层之间的连接减少。我们得出结论，随着特质身体攻击性的增加，儿童的社会意图归因与更强烈的早期面部和语音处理区域的激活有关。
