纳洛酮可减轻离体灌注大鼠心脏心肌缺血再灌注后环磷酸腺苷（cAMP）水平的升高及心律失常。
Naloxone attenuates augmentation of cAMP levels and arrhythmias following myocardial ischaemia and reperfusion in the isolated perfused rat heart.
作者信息
Lee A Y, Wong T M
出版信息
Clin Exp Pharmacol Physiol. 1986 Oct;13(10):707-10. doi: 10.1111/j.1440-1681.1986.tb02411.x.
The effects of myocardial ischaemia and reperfusion on arrhythmias and cAMP levels were studied using the Langendoff isolated perfused rat heart preparation. Myocardial ischaemia and reperfusion caused arrhythmias and augmentation of cAMP levels concurrently, supporting the suggestion that myocardial cAMP is related to arrhythmias. Pretreatment with naloxone attenuated both arrhythmias and augmentation of cAMP levels to a similar extent. The results suggest that the anti-arrhythmic effect of naloxone may involve myocardial cAMP.
利用Langendoff离体灌注大鼠心脏标本，研究了心肌缺血和再灌注对心律失常及环磷酸腺苷（cAMP）水平的影响。心肌缺血和再灌注同时引发心律失常并使cAMP水平升高，这支持了心肌cAMP与心律失常有关的观点。用纳洛酮预处理可在相似程度上减轻心律失常及cAMP水平的升高。结果表明，纳洛酮的抗心律失常作用可能涉及心肌cAMP。
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