Department of Botany, 430 Lincoln Drive, University of Wisconsin-Madison, WI 53706, United States; Laboratory of Molecular and Cellular Biology, 1525 Linden Drive, University of Wisconsin-Madison, Madison, WI 53706, United States.
Department of Botany, 430 Lincoln Drive, University of Wisconsin-Madison, WI 53706, United States; Laboratory of Molecular and Cellular Biology, 1525 Linden Drive, University of Wisconsin-Madison, Madison, WI 53706, United States; Department of Genetics, 405 Henry Mall, University of Wisconsin-Madison, Madison, WI 53706, United States.
Curr Opin Plant Biol. 2018 Dec;46:113-121. doi: 10.1016/j.pbi.2018.09.004. Epub 2018 Sep 26.
Autophagy mediates the delivery of cytoplasmic content to vacuoles or lysosomes for degradation or storage. The best characterized autophagy route called macroautophagy involves the sequestration of cargo in double-membrane autophagosomes and is conserved in eukaryotes, including plants. Recently, several new receptors, some of them plant-specific, that select cargo for macroautophagy have been identified. Some of these receptors appear to participate in regulation of competing catabolic pathways, for example proteasome-mediated versus autophagic degradation under specific stress conditions. Vacuolar microautophagy, a process by which the vacuole directly engulf cytoplasmic material, also occurs in plants but its underlying molecular mechanisms are yet to be elucidated.
自噬介导细胞质内容物被递送至液泡或溶酶体进行降解或储存。研究最为透彻的自噬途径称为巨自噬,该途径涉及将货物隔离在双层自噬体中,在包括植物在内的真核生物中都保守存在。最近,已经鉴定出几种新的受体,其中一些是植物特异性的,它们可以选择用于巨自噬的货物。这些受体中的一些似乎参与了竞争分解代谢途径的调节,例如在特定应激条件下,蛋白酶体介导的降解与自噬降解之间的竞争。液泡微自噬是液泡直接吞噬细胞质物质的过程,也发生在植物中,但它的潜在分子机制尚未阐明。