Csaba G, Kovács P
Exp Cell Biol. 1986;54(5-6):333-7. doi: 10.1159/000163372.
Signal molecules (hormones) can induce a hormonal imprinting in the unicellular Tetrahymena, as judged from an increase in binding capacity on reexposure in the subsequent generations. Structurally unrelated polypeptide hormones (insulin, FSH) neutralize each other's effect, whereas related hormones (TSH-FSH) may amplify or depress it. The non-signal polypeptide molecule BSA prevents hormonal imprinting on combined exposure. The glucocorticoid hormone enhances binding capacity for insulin (as in mammals) and increases its imprinting potential, whereas on TSH and FSH it has no similar effects. The amino acid hormone serotonin increases the binding capacity for TSH and FSH in non-pretreated cells, but depresses rather than stimulates the imprinting potential of these hormones, measured in the case of the second encounter.
信号分子（激素）可在单细胞四膜虫中诱导激素印记，这可从后续世代再次接触时结合能力的增加来判断。结构不相关的多肽激素（胰岛素、促卵泡激素）会相互抵消彼此的作用，而相关激素（促甲状腺激素 - 促卵泡激素）可能会放大或抑制其作用。非信号多肽分子牛血清白蛋白在联合暴露时可防止激素印记。糖皮质激素可增强对胰岛素的结合能力（如在哺乳动物中一样）并增加其印记潜力，而对促甲状腺激素和促卵泡激素则没有类似作用。氨基酸激素血清素可增加未预处理细胞中对促甲状腺激素和促卵泡激素的结合能力，但在第二次接触时测量，它会抑制而非刺激这些激素的印记潜力。
