无义蛋白在猴病毒40复制和成熟途径调控中的作用。
Role of the agnoprotein in regulation of simian virus 40 replication and maturation pathways.
作者信息
Hou-Jong M H, Larsen S H, Roman A
出版信息
J Virol. 1987 Mar;61(3):937-9. doi: 10.1128/JVI.61.3.937-939.1987.
Abstract
Analysis of two agnogene mutants, dl2304 deleted over the entire agnogene and in2379 carrying a 2-base insert, indicated that the mutant phenotype of small plaque formation must be the result of a defect late in the maturation pathway. Both mutants were removed from the pool of molecules available for replication with wild-type kinetics. Whereas dl2304 was somewhat reduced in its rate of progression from chromatin to previrions-virions, in2379, which produced even smaller plaques than dl2304 did, progressed with wild-type kinetics. Therefore, the agnoprotein was not required for progression from chromatin to previrions.
摘要
对两个无基因（agnogene）突变体的分析表明，小噬菌斑形成的突变表型必定是成熟途径后期缺陷的结果。这两个突变体分别是整个无基因缺失的dl2304和携带2个碱基插入的in2379。两个突变体均以野生型动力学从可用于复制的分子池中去除。虽然dl2304从染色质到前病毒颗粒 - 病毒颗粒的进展速率有所降低，但产生比dl2304更小噬菌斑的in2379却以野生型动力学进展。因此，从染色质到前病毒颗粒的进展不需要agnoprotein。
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2
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3
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5
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