Saribas A Sami, Jensen Liselotte E, Safak Mahmut
Lewis Katz School of Medicine at Temple University, Department of Microbiology, Immunology and Inflammation Center for Neurovirology and Gene Editing, 3500 N. Broad Street, Philadelphia, PA, 19140, USA.
Lewis Katz School of Medicine at Temple University, Department of Microbiology, Immunology and Inflammation, Center for Inflammation and Lung Research, 3500 N. Broad Street, Philadelphia, PA, 19140, USA.
Virology. 2025 Jan;602:110310. doi: 10.1016/j.virol.2024.110310. Epub 2024 Nov 22.
The polyomavirus family consists of a highly diverse group of small DNA viruses isolated from various species, including humans. Some family members have been used as model systems to understand the fundamentals of modern biology. After the discovery of the first two human polyomaviruses (JC virus and BK virus) during the early 1970s, their current number reached 14 today. Some family members cause considerably severe human diseases, including polyomavirus-associated nephropathy (PVAN), progressive multifocal leukoencephalopathy (PML), trichodysplasia spinulosa (TS) and Merkel cell carcinoma (MCC). Polyomaviruses encode universal regulatory and structural proteins, but some members express additional virus-specific proteins and microRNA, which significantly contribute to the viral biology, cell transformation, and perhaps progression of the disease that they are associated with. In the current review, we summarized the recent advances in discovery, and functional and structural analysis of those viral proteins and microRNA.
多瘤病毒科由一组高度多样化的小型DNA病毒组成，这些病毒从包括人类在内的各种物种中分离出来。一些家族成员已被用作模型系统来理解现代生物学的基本原理。在20世纪70年代初发现前两种人类多瘤病毒（JC病毒和BK病毒）之后，目前其数量已达14种。一些家族成员会引发相当严重的人类疾病，包括多瘤病毒相关性肾病（PVAN）、进行性多灶性白质脑病（PML）、棘状毛发发育异常（TS）和默克尔细胞癌（MCC）。多瘤病毒编码通用的调节蛋白和结构蛋白，但一些成员还表达额外的病毒特异性蛋白和微小RNA，这对病毒生物学、细胞转化以及它们所关联疾病的进展有显著贡献。在本综述中，我们总结了这些病毒蛋白和微小RNA在发现、功能及结构分析方面的最新进展。
