Department of Global Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Nutrients. 2018 Sep 29;10(10):1384. doi: 10.3390/nu10101384.
Sickle cell disease (SCD) is a genetic disorder resulting from the presence of mutated hemoglobin S (HbS). Homozygous carriers will present with early manifestations of painful vaso-occlusive crises. SCD patients have been reported to be severely deficient in vitamin D (<20 ng/mL). Four years (2010⁻2014) of individual de-identified Sickle Cell Clinic of Southern Louisiana (SCCSL-SCD) patient records were analyzed for vitamin D status and the level of crisis-related ER/hospital utilization. To determine the dietary, and behavioral mediators of SCD-crisis in our study population, a cohort of 102 SCCSL-SCD patients were administered a survey that evaluated sun exposure, dietary behaviors, and pain frequency and severity. Patients with circulating levels of 25(OH)D₃ less than 14.1 ng/mL reported having more crisis-related hospital visits per year (10) than patients with 25(OH)D₃ serum levels >34 ng/mL. The result of the dietary survey detailed a relationship between patients who reported to have "Almost Never" consumed fish or milk in their diets and more frequent hospital stays and ER visits than those who reported consuming these products on a daily basis. Those who consumed these foods in their diet several times a month also had fewer ER visits when compared to the "Almost Never" category.
镰状细胞病（SCD）是一种由突变血红蛋白 S（HbS）引起的遗传性疾病。纯合子携带者会出现早期疼痛性血管阻塞危象。据报道，SCD 患者严重缺乏维生素 D（<20ng/mL）。分析了来自路易斯安那州南部镰状细胞诊所（SCCSL-SCD）的四年（2010-2014 年）个体匿名患者记录，以评估维生素 D 状况和与危象相关的急诊/住院利用率。为了确定我们研究人群中 SCD 危象的饮食和行为中介因素，对 102 名 SCCSL-SCD 患者进行了一项调查，该调查评估了阳光暴露、饮食行为以及疼痛频率和严重程度。25（OH）D₃循环水平<14.1ng/mL 的患者报告每年与危象相关的住院就诊次数（10 次）多于 25（OH）D₃血清水平>34ng/mL 的患者。饮食调查的结果详细说明了报告几乎从不食用鱼类或牛奶的患者与那些每天食用这些产品的患者相比，住院和急诊就诊次数更多。与“几乎从不”食用这些食物的患者相比，那些每月食用这些食物几次的患者急诊就诊次数也更少。
