Lehmann M, Gastmann U, Tauber R, Weiler C, Pilot R, Hirsch F H, Auch-Schwelk W, Keul J
Klin Wochenschr. 1986 Dec 1;64(23):1249-54. doi: 10.1007/BF01734468.
We evaluated sympathetic nervous system function in a patient with primary orthostatic hypotension. Plasma catecholamine levels--except for dopamine levels--and urinary catecholamine excretion were decreased, alpha-adrenoreceptor responsiveness to noradrenaline and beta-adrenoreceptor responsiveness to isoproterenol were increased according to increased beta-2-adrenoreceptor density on intact polymorphonuclear leukocytes. Alpha-2-adrenoreceptor density on intact platelets and adrenaline-induced platelet aggregation in vitro, however, were unchanged. We evolved a therapeutic regimen with fludrocortisone, propranolol, and dihydroergotamine that allowed the patient to resume nearly a regular degree of mobility.
我们评估了一名原发性直立性低血压患者的交感神经系统功能。血浆儿茶酚胺水平（多巴胺水平除外）和尿儿茶酚胺排泄量均降低，根据完整多形核白细胞上β-2肾上腺素能受体密度增加，α-肾上腺素能受体对去甲肾上腺素的反应性和β-肾上腺素能受体对异丙肾上腺素的反应性增加。然而，完整血小板上的α-2肾上腺素能受体密度和体外肾上腺素诱导的血小板聚集未发生变化。我们制定了一种使用氟氢可的松、普萘洛尔和双氢麦角胺的治疗方案，使该患者能够恢复几乎正常的活动程度。
