用于超声研究的脑模拟组织体模的研制

Development of a Tissue-Mimicking Phantom of the Brain for Ultrasonic Studies.

作者信息

Taghizadeh Somayeh, Labuda Cecille, Mobley Joel

机构信息

National Center for Physical Acoustics and Department of Physics and Astronomy, University of Mississippi, University, Mississippi, USA.

出版信息

Ultrasound Med Biol. 2018 Dec;44(12):2813-2820. doi: 10.1016/j.ultrasmedbio.2018.08.012. Epub 2018 Sep 28.

DOI:10.1016/j.ultrasmedbio.2018.08.012

PMID:30274683

Abstract

Constructing tissue-mimicking phantoms of the brain for ultrasonic studies is complicated by the low backscatter coefficient of brain tissue, causing difficulties in simultaneously matching the backscatter and attenuation properties. In this work, we report on the development of a polyvinyl alcohol-based tissue-mimicking phantom with properties approaching those of human brain tissue. Polyvinyl alcohol was selected as the base material for the phantom as its properties can be varied by freeze-thaw cycling, variations in concentration and the addition of scattering inclusions, allowing some independent control of backscatter and attenuation. The ultrasonic properties (including speed of sound, attenuation and backscatter) were optimized using these methods with talc powder as an additive. It was determined that the ultrasonic properties of the phantom produced in this study are best matched to brain tissue in the frequency range 1-3 MHz, indicating its utility for laboratory ultrasonic studies in this frequency range.

摘要

构建用于超声研究的脑组织模拟体模颇具复杂性，因为脑组织的背向散射系数较低，这使得同时匹配背向散射和衰减特性存在困难。在这项工作中，我们报告了一种基于聚乙烯醇的组织模拟体模的开发情况，其特性接近人类脑组织。选择聚乙烯醇作为体模的基础材料，是因为其特性可通过冻融循环、浓度变化以及添加散射内含物来改变，从而能够对背向散射和衰减进行一定程度的独立控制。使用这些方法并以滑石粉作为添加剂，对超声特性（包括声速、衰减和背向散射）进行了优化。结果确定，本研究中制备的体模的超声特性在1 - 3兆赫兹频率范围内与脑组织最为匹配，这表明其在该频率范围内用于实验室超声研究具有实用性。